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Nup88 nucleoporin 88 [ Mus musculus (house mouse) ]

Gene ID: 19069, updated on 2-Nov-2024

Summary

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Official Symbol
Nup88provided by MGI
Official Full Name
nucleoporin 88provided by MGI
Primary source
MGI:MGI:104900
See related
Ensembl:ENSMUSG00000040667 AllianceGenome:MGI:104900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nup84; Prei2
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in nuclear envelope and nucleoplasm. Predicted to be part of nuclear pore. Is expressed in central nervous system; early conceptus; gonad; and sensory organ. Human ortholog(s) of this gene implicated in fetal akinesia deformation sequence syndrome 4. Orthologous to human NUP88 (nucleoporin 88). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 33.6), CNS E14 (RPKM 26.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nup88 in Genome Data Viewer
Location:
11 B4; 11 43.21 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70833884..70860799, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70943058..70969973, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene ribosomal protein L23A, pseudogene 2 Neighboring gene predicted gene 12322 Neighboring gene STARR-seq mESC enhancer starr_29882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70783671-70783780 Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH-box helicase 33 Neighboring gene predicted gene, 22297

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB. Takahashi N, et al. Biochem Biophys Res Commun, 2008 Sep 26. PMID 18621024
  2. Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. Andres-Hernando A, et al. J Biol Chem, 2008 Sep 5. PMID 18606815, Free PMC Article
  3. Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons. Khalaf B, et al. J Cell Sci, 2019 Sep 26. PMID 31427429
  4. Expression patterns of novel genes during mouse preimplantation embryogenesis. Temeles GL, et al. Mol Reprod Dev, 1994 Feb. PMID 7545925
  5. Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. Naylor RM, et al. J Clin Invest, 2016 Feb. PMID 26731471, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes.
    Title: Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus.
  2. Nup88 regulates the activity of NF-kappaB at the level of nucleocytoplasmic transport.
    Title: Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup88
Names
88 kDa nucleoporin
preimplantation protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083331.2 → NP_001076800.1  nuclear pore complex protein Nup88 isoform 2

    See identical proteins and their annotated locations for NP_001076800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AK028563, AK050893, AK160619
    Consensus CDS
    CCDS36206.1
    UniProtKB/Swiss-Prot
    Q80Z13, Q8CEC0, Q8K090
    UniProtKB/TrEMBL
    Q3TM09
    Related
    ENSMUSP00000048101.5, ENSMUST00000035283.11
    Conserved Domains (2) summary
    pfam10168
    Location:14 → 751
    Nup88; Nuclear pore component
    pfam13863
    Location:570 → 678
    DUF4200; Domain of unknown function (DUF4200)

  2. NM_001276406.1 → NP_001263335.1  nuclear pore complex protein Nup88 isoform 3

    See identical proteins and their annotated locations for NP_001263335.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, compared to variant 2. The encoded isoform (3) is shorter, compared to isoform 2.
    Source sequence(s)
    AK028563, AK050893, AK160619
    Consensus CDS
    CCDS70233.1
    UniProtKB/TrEMBL
    Q3TM09
    Related
    ENSMUSP00000104171.2, ENSMUST00000108531.8
    Conserved Domains (2) summary
    pfam10168
    Location:14 → 745
    Nup88; Nuclear pore component
    cl12013
    Location:589 → 688
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_172394.3 → NP_765982.2  nuclear pore complex protein Nup88 isoform 1

    See identical proteins and their annotated locations for NP_765982.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses two alternate splice sites in the coding region, compared to variant 2. The encoded isoform (1) is shorter, compared to isoform 2.
    Source sequence(s)
    AK050893, AK160619
    Consensus CDS
    CCDS36207.1
    UniProtKB/TrEMBL
    Q3TM09, Q5QNU0
    Related
    ENSMUSP00000104170.2, ENSMUST00000108530.2
    Conserved Domains (2) summary
    pfam10168
    Location:14 → 740
    Nup88; Nuclear pore component
    cl12013
    Location:584 → 683
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. NR_075087.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, alternate splice sites in three internal exons, and lacks two internal exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK050893, AK139738, AK160619
    Related
    ENSMUST00000178253.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70833884..70860799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEC0.1 GenPept UniProtKB/Swiss-Prot:Q8CEC0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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