bre-4 Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: bre-4
Official Full Name: Beta-1,4-N-acetylgalactosaminyltransferase bre-4
Primary source: WormBase:WBGene00000269
Locus tag: CELE_Y73E7A.7
See related: AllianceGenome:WB:WBGene00000269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables beta-1,4-N-acetylgalactosaminyltransferase activity. Involved in positive regulation of Notch signaling pathway; protein glycosylation; and response to toxic substance. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to several human genes including B4GALT1 (beta-1,4-galactosyltransferase 1) and B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycosphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_001370927.1

NP_490872.1

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The following sections contain reference sequences that belong to a specific genome build. Explain