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bre-4 Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [ Caenorhabditis elegans ]

Gene ID: 190668, updated on 2-Nov-2024

Summary

Official Symbol
bre-4
Official Full Name
Beta-1,4-N-acetylgalactosaminyltransferase bre-4
Primary source
WormBase:WBGene00000269
Locus tag
CELE_Y73E7A.7
See related
AllianceGenome:WB:WBGene00000269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables beta-1,4-N-acetylgalactosaminyltransferase activity. Involved in positive regulation of Notch signaling pathway; protein glycosylation; and response to toxic substance. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to several human genes including B4GALT1 (beta-1,4-galactosyltransferase 1) and B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See bre-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (1621314..1628486, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein BFR2 Neighboring gene Bladder cancer-associated protein Neighboring gene WD and tetratricopeptide repeats protein 1;WD_REPEATS_REGION domain-containing protein Neighboring gene Coiled-coil domain-containing protein Neighboring gene Mucin-5AC

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycosphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Beta-1,4-N-acetylgalactosaminyltransferase bre-4
NP_001370927.1
  • Confirmed by transcript evidence
NP_490872.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1621314..1628486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058471.2NP_490872.1  Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490872.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GUM2, W6SB74
    Conserved Domains (1) summary
    cd00899
    Location:147365
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. NM_001383737.2NP_001370927.1  Beta-1,4-N-acetylgalactosaminyltransferase bre-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd00899
    Location:1200
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids