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pipp-4P Phosphatidylinositol-4,5-bisphosphate 4-phosphatase [ Caenorhabditis elegans ]

Gene ID: 190605, updated on 28-Oct-2024

Summary

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Official Symbol
pipp-4P
Official Full Name
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Primary source
WormBase:WBGene00022167
Locus tag
CELE_Y71H2AM.2
See related
AllianceGenome:WB:WBGene00022167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in endosome; lysosome; and membrane. Predicted to be active in bounding membrane of organelle and plasma membrane. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1) and PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See pipp-4P in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (2819278..2826588)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase E3D Neighboring gene Elongation factor Tu, mitochondrial Neighboring gene N(6)-L-threonylcarbamoyladenine synthase Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Thioredoxin domain-containing protein 17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagocytic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
NP_001411904.1
  • Confirmed by transcript evidence
NP_497624.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2819278..2826588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001424978.1 → NP_001411904.1  Phosphatidylinositol-4,5-bisphosphate 4-phosphatase [Caenorhabditis elegans]

    Status: REVIEWED

  2. NM_065223.6 → NP_497624.3  Phosphatidylinositol-4,5-bisphosphate 4-phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497624.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL29
    Conserved Domains (1) summary
    pfam09788
    Location:59 → 217
    Tmemb_55A; Transmembrane protein 55A
Nucleotide Protein
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