Ppp1r17 protein phosphatase 1, regulatory subunit 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r17provided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 17provided by MGI
Primary source: MGI:MGI:1333876
See related: Ensembl:ENSMUSG00000002930 AllianceGenome:MGI:1333876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gsbs; Ppp1r2
Summary: Enables protein serine/threonine phosphatase inhibitor activity. Involved in regulation of phosphatase activity. Predicted to be located in cytosol. Is expressed in alimentary system; cerebellum; ganglia; heart; and neural retina. Human ortholog(s) of this gene implicated in familial hypercholesterolemia. Orthologous to human PPP1R17 (protein phosphatase 1 regulatory subunit 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 38.8) and CNS E11.5 (RPKM 4.9) See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (55994482..56009674)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (56017497..56032689)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DMH[Ppp1r17] neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication.
Title: DMH(Ppp1r17) neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication.
PPARdelta dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment.
Title: PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment.
Restriction of food intake by PPP1R17-expressing neurons in the DMH.
Title: Restriction of food intake by PPP1R17-expressing neurons in the DMH.
G-substrate reduces vulnerability of dopaminergic cells in models of Parkinson's disease.
Title: An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.
The mice with targeted G-substrate gene knockout results in the impairment of cerebellum-dependent long-term memory (optokinetic response adaptation) without influence on short-term one.
Title: Dual involvement of G-substrate in motor learning revealed by gene deletion.
retinal G-substrate plays a role as a downstream component of the NO-cGMP-PKG pathway. The co-localization of retinal G-substrate with protein Ser/Thr phosphatases suggests that it acts as an endogenous protein phosphatase inhibitor.
Title: Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 17

Names: G substrate; protein phosphatase 1, regulatory (inhibitor) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.