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S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens (human) ]

Gene ID: 1901, updated on 23-Mar-2024

Summary

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Official Symbol
S1PR1provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 1provided by HGNC
Primary source
HGNC:HGNC:3165
See related
Ensembl:ENSG00000170989 MIM:601974; AllianceGenome:HGNC:3165
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
Summary
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
1p21.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (101236899..101242313)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (101085760..101091176)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101702455..101707869)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1395 Neighboring gene S1PR1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1396 Neighboring gene MPRA-validated peak339 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1397 Neighboring gene ribosomal protein S20 pseudogene 6 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:101724915-101726114 Neighboring gene peptidylprolyl isomerase A pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function. Weigel C, et al. J Biol Chem, 2023 Jun. PMID 37142226, Free PMC Article
  2. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Laroche FJF, et al. Cells, 2023 Mar 23. PMID 37048053, Free PMC Article
  3. Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients. Gray N, et al. Int J Mol Sci, 2022 Dec 17. PMID 36555755, Free PMC Article
  4. Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke. Huang H, et al. FASEB J, 2022 Dec. PMID 36394527
  5. New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1. Ye L, et al. Stem Cell Res Ther, 2022 Oct 8. PMID 36209115, Free PMC Article

See all (227) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.
    Title: Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.
  2. S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.
    Title: S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.
  3. S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.
    Title: S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.
  4. CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus.
    Title: CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus.
  5. HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.
    Title: HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.
  6. Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.
    Title: Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.
  7. Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.
    Title: Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.
  8. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.
    Title: S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.
  9. Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients.
    Title: Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients.
  10. Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke.
    Title: Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke.
Submit: New GeneRIF Correction See all GeneRIFs (190)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of sphingosine-1-phosphate receptor 1 (S1PR1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ58121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sphingolipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine-1-phosphate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine-1-phosphate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in T cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood vessel maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle tissue growth involved in heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in heart trabecula morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sphingosine 1-phosphate receptor 1
Names
S1P receptor 1
S1P receptor Edg-1
endothelial differentiation G-protein coupled receptor 1
endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
sphingosine 1-phosphate receptor EDG1
sphingosine 1-phosphate receptor Edg-1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016181.1 RefSeqGene

    Range
    5271..9770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320730.2 → NP_001307659.1  sphingosine 1-phosphate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL109741, BP236900
    Consensus CDS
    CCDS777.1
    UniProtKB/Swiss-Prot
    D3DT66, P21453, Q9BYY4, Q9NYN8
    UniProtKB/TrEMBL
    Q7L853
    Conserved Domains (1) summary
    cd15346
    Location:46 → 322
    7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001400.5 → NP_001391.2  sphingosine 1-phosphate receptor 1

    See identical proteins and their annotated locations for NP_001391.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL109741
    Consensus CDS
    CCDS777.1
    UniProtKB/Swiss-Prot
    D3DT66, P21453, Q9BYY4, Q9NYN8
    UniProtKB/TrEMBL
    Q7L853
    Related
    ENSP00000305416.6, ENST00000305352.7
    Conserved Domains (1) summary
    cd15346
    Location:46 → 322
    7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_174345.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109741

  2. NR_174346.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109741

  3. NR_174347.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109741

  4. NR_174348.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109741

  5. NR_174349.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109741

  6. NR_174350.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109741

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    101236899..101242313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007095678.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    101085760..101091176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485945.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21453.2 GenPept UniProtKB/Swiss-Prot:P21453

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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