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grh-1 CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190048, updated on 12-Jun-2024

Summary

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Gene symbol
grh-1
Gene description
CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein
Locus tag
CELE_Y48G8AR.1
See related
AllianceGenome:WB:WBGene00001707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in aging. Located in nucleus. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to several human genes including GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See grh-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (1258201..1268155, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene HECT domain-containing protein Neighboring gene ncRNA Neighboring gene nucleoside-diphosphate kinase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1. Meeuse MWM, et al. EMBO J, 2023 Feb 15. PMID 36688410, Free PMC Article
  2. SPIRE, a modular pipeline for eQTL analysis of RNA-Seq data, reveals a regulatory hotspot controlling miRNA expression in C. elegans. Kel I, et al. Mol Biosyst, 2016 Oct 18. PMID 27722582
  3. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Grigolon G, et al. Nat Commun, 2022 Jan 10. PMID 35013237, Free PMC Article
  4. Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead. Venkatesan K, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888489, Free PMC Article
  5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.
    Title: C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.
  2. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
    Title: Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
  3. characterized GRH-1 a member of an ancient duplicated transcription factor family, LSF/Grainyhead; phenotype similar to Drosophila grainyhead mutants, suggesting conservation of the developmental role of these family members during evolution (GRH-1).
    Title: Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein
NP_001293411.1
  • Partially confirmed by transcript evidence
NP_001293412.1
  • Partially confirmed by transcript evidence
NP_490837.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1258201..1268155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058436.6 → NP_490837.2  Grainyhead-like protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490837.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDF0
    Conserved Domains (1) summary
    pfam04516
    Location:198 → 385
    CP2; CP2 transcription factor

  2. NM_001306482.4 → NP_001293411.1  Grh/CP2 DB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RT88
    Conserved Domains (1) summary
    pfam04516
    Location:198 → 386
    CP2; CP2 transcription factor

  3. NM_001306483.3 → NP_001293412.1  CP2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293412.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SB79
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EDF0.1

Gene LinkOut

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