Pou2f2 POU domain, class 2, transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pou2f2provided by MGI
Official Full Name: POU domain, class 2, transcription factor 2provided by MGI
Primary source: MGI:MGI:101897
See related: Ensembl:ENSMUSG00000008496 AllianceGenome:MGI:101897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Otf2; Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and spermidine transmembrane transporter activity. Involved in cellular response to virus; positive regulation of macromolecule biosynthetic process; and spermidine transport. Acts upstream of or within cell maturation; mature B cell differentiation; and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 14.3), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.73 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24790111..24879292, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25087350..25180797, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2.
Title: POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2.
The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
Title: The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
OBF1 and Oct factors control the germinal center transcriptional program.
Title: OBF1 and Oct factors control the germinal center transcriptional program.
Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Title: Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
Title: Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
findings, combined with the predominantly B-cell-restricted expression of OCT2 and the absence of a systemic phenotype in our knockout mice, suggest that an OCT2-targeted therapeutic strategy would be efficacious in both major subtypes of DLBCL while avoiding systemic toxicity
Title: Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.
overexpression of DDX60 did not potentiate IFN induction
Title: NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells.
Oct2 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
Title: Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
The circadian expression of OCT2 was closely related to the dose-time dependency of cisplatin incorporation into renal DNA.
Title: Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.
These findings indicate that Oct-2 induction of MiR-210 provides a novel inhibitory mechanism for the control of B cells and autoantibody production.
Title: MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:224421

NoName (e-PCR)
- UniSTS:489161

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables spermidine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mature B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermidine transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: POU domain, class 2, transcription factor 2

Names: lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; octamer-binding protein 2; octamer-binding transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163554.2 → NP_001157026.1 POU domain, class 2, transcription factor 2 isoform 4

See identical proteins and their annotated locations for NP_001157026.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an additional exon in the 3' coding region, as compared to variant 1. The resulting isoform (4) has a longer and different C-terminus, as compared to isoform 1.

Source sequence(s)

AC120393

Consensus CDS

CCDS52144.1

UniProtKB/Swiss-Prot

Q00196

Related

ENSMUSP00000104056.4, ENSMUST00000108418.11

Conserved Domains (2) summary

smart00352
Location:179 → 253

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:284 → 337

Homeobox; Homeobox domain
NM_001163555.2 → NP_001157027.1 POU domain, class 2, transcription factor 2 isoform 3

See identical proteins and their annotated locations for NP_001157027.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (3) is longer and has the same N- and C-termini, as compared to isoform 1.

Source sequence(s)

AC120393

Consensus CDS

CCDS52145.1

UniProtKB/TrEMBL

H3BKB7

Related

ENSMUSP00000104055.3, ENSMUST00000108417.10

Conserved Domains (2) summary

smart00352
Location:201 → 275

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:306 → 360

Homeobox; Homeobox domain
NM_001163556.2 → NP_001157028.1 POU domain, class 2, transcription factor 2 isoform 1

See identical proteins and their annotated locations for NP_001157028.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC120393

Consensus CDS

CCDS52143.1

UniProtKB/Swiss-Prot

Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q3KR47, Q3U127, Q5XML1, Q5XML2, Q61995, Q61996, Q64245

UniProtKB/TrEMBL

H3BKB7

Related

ENSMUSP00000135075.2, ENSMUST00000175774.9

Conserved Domains (2) summary

smart00352
Location:179 → 253

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:284 → 338

Homeobox; Homeobox domain
NM_001417132.1 → NP_001404061.1 POU domain, class 2, transcription factor 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417133.1 → NP_001404062.1 POU domain, class 2, transcription factor 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417134.1 → NP_001404063.1 POU domain, class 2, transcription factor 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417135.1 → NP_001404064.1 POU domain, class 2, transcription factor 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417136.1 → NP_001404065.1 POU domain, class 2, transcription factor 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417137.1 → NP_001404066.1 POU domain, class 2, transcription factor 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417138.1 → NP_001404067.1 POU domain, class 2, transcription factor 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417139.1 → NP_001404068.1 POU domain, class 2, transcription factor 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC120393
NM_001417140.1 → NP_001404069.1 POU domain, class 2, transcription factor 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC120393

Related

ENSMUSP00000104054.3, ENSMUST00000108416.10
NM_001417141.1 → NP_001404070.1 POU domain, class 2, transcription factor 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC120393
NM_011138.3 → NP_035268.2 POU domain, class 2, transcription factor 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (2) is longer and has the same N- and C-termini, as compared to isoform 1.

Source sequence(s)

AC120393

Consensus CDS

CCDS39834.1

UniProtKB/TrEMBL

H3BKB7

Related

ENSMUSP00000104053.3, ENSMUST00000108415.10

Conserved Domains (3) summary

smart00352
Location:195 → 269

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:300 → 354

Homeobox; Homeobox domain

pfam09770
Location:116 → 193

PAT1; Topoisomerase II-associated protein PAT1