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bus-4 N-acetylgalactosaminide beta-1,3-galactosyltransferase [ Caenorhabditis elegans ]

Gene ID: 188726, updated on 18-Sep-2024

Summary

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Official Symbol
bus-4
Official Full Name
N-acetylgalactosaminide beta-1,3-galactosyltransferase
Primary source
WormBase:WBGene00044620
Locus tag
CELE_T22B11.2
See related
AllianceGenome:WB:WBGene00044620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in O-glycan processing, core 1. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in intestine; pharynx; and seam cell. Human ortholog(s) of this gene implicated in Tn polyagglutination syndrome. Orthologous to human C1GALT1C1 (C1GALT1 specific chaperone 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See bus-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (4688269..4691936)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene AMOP domain-containing protein Neighboring gene 2-oxoglutarate dehydrogenase, mitochondrial;Transketolase-like pyrimidine-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans bacterial pathogen resistant bus-4 mutants produce altered mucins. Parsons LM, et al. PLoS One, 2014. PMID 25296196, Free PMC Article
  2. The hmsHFRS operon of Xenorhabdus nematophila is required for biofilm attachment to Caenorhabditis elegans. Drace K, et al. Appl Environ Microbiol, 2008 Jul. PMID 18515487, Free PMC Article
  3. Pmr-1 gene affects susceptibility of Caenorhabditis elegans to Staphylococcus aureus infection through glycosylation and stress response pathways' alterations. Schifano E, et al. Virulence, 2019 Dec. PMID 31771413, Free PMC Article
  4. Caenorhabditis elegans mutants resistant to attachment of Yersinia biofilms. Darby C, et al. Genetics, 2007 May. PMID 17339204, Free PMC Article
  5. Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans. Gravato-Nobre MJ, et al. Genetics, 2011 Jan. PMID 20980242, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylgalactosaminide beta-1,3-galactosyltransferase
NP_500615.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4688269..4691936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068214.3 → NP_500615.2  N-acetylgalactosaminide beta-1,3-galactosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500615.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44563
    Conserved Domains (1) summary
    cl21608
    Location:104 → 235
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein
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