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nth-1 Endonuclease III homolog [ Caenorhabditis elegans ]

Gene ID: 187770, updated on 2-Nov-2024

Summary

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Official Symbol
nth-1
Official Full Name
Endonuclease III homolog
Primary source
WormBase:WBGene00011201
Locus tag
CELE_R10E4.5
See related
AllianceGenome:WB:WBGene00011201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables 5-formyluracil DNA N-glycosylase activity and 5-hydroxymethyluracil DNA N-glycosylase activity. Involved in cellular response to hydrogen peroxide and depyrimidination. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nth-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (4291543..4294253, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene DNA replication licensing factor mcm-5 Neighboring gene DUF1996 domain-containing protein Neighboring gene GP-PDE domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. Kassahun H, et al. DNA Repair (Amst), 2018 Jan. PMID 29202295
  2. Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region. Morinaga H, et al. DNA Repair (Amst), 2009 Jul 4. PMID 19481506
  3. In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans. Hunter SE, et al. DNA Repair (Amst), 2012 Nov 1. PMID 22959841, Free PMC Article
  4. A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways. Fensgård Ø, et al. Aging (Albany NY), 2010 Mar 31. PMID 20382984, Free PMC Article
  5. The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans. Elsakrmy N, et al. Front Cell Dev Biol, 2020. PMID 33344454, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we could detect no deficiency in base excision repair in the nth-1 strain.
    Title: In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans.
  2. Loss of NTH-1, the only Base Excision Repair enzyme known to initiate repair of oxidative DNA damage in C. elegans, restores normal lifespan of the short-lived Nucleotide Excision Repair deficient xpa-1 mutant.
    Title: A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways.
  3. Data show that the protein encoded by the sequence containing both R10E4.5 and the 117-bp region upstream from it, and found that the protein had the NTH activity.
    Title: Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 5-formyluracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-hydroxymethyluracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair, AP site formation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in depyrimidination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Endonuclease III homolog
NP_001254907.1
  • Confirmed by transcript evidence
NP_001254908.1
  • Confirmed by transcript evidence
NP_001254909.1
  • Confirmed by transcript evidence
NP_001369882.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4291543..4294253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267978.2 → NP_001254907.1  Endonuclease III homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54137
    Conserved Domains (3) summary
    smart00525
    Location:221 → 239
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    smart00478
    Location:71 → 219
    ENDO3c; endonuclease III
    COG0177
    Location:34 → 239
    Nth; Endonuclease III [Replication, recombination and repair]

  2. NM_001384068.1 → NP_001369882.1  Endonuclease III homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C7G4V3, D5MCR0, D5MCR1, D5MCR2, P54137
    Conserved Domains (1) summary
    COG0177
    Location:39 → 244
    Nth; Endonuclease III [Replication, recombination and repair]

  3. NM_001267979.3 → NP_001254908.1  Endonuclease III homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54137
    Conserved Domains (3) summary
    smart00525
    Location:152 → 170
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    smart00478
    Location:2 → 150
    ENDO3c; endonuclease III
    COG0177
    Location:1 → 170
    Nth; Endonuclease III [Replication, recombination and repair]

  4. NM_001267980.3 → NP_001254909.1  Endonuclease III homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254909.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54137
    Conserved Domains (2) summary
    smart00525
    Location:68 → 86
    FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
    cl23768
    Location:2 → 75
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54137.2

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