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Lypla1 lysophospholipase 1 [ Mus musculus (house mouse) ]

Gene ID: 18777, updated on 29-Oct-2024

Summary

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Official Symbol
Lypla1provided by MGI
Official Full Name
lysophospholipase 1provided by MGI
Primary source
MGI:MGI:1344588
See related
Ensembl:ENSMUSG00000025903 AllianceGenome:MGI:1344588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APT-1; LPL-I; Pla1a; Gm39587
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport. Located in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and skeleton. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in liver adult (RPKM 20.2), placenta adult (RPKM 17.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lypla1 in Genome Data Viewer
Location:
1 A1; 1 1.79 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4878046..4916958)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4807823..4846735)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (lipoamide) beta pseudogene Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene STARR-seq mESC enhancer starr_00039 Neighboring gene STARR-seq mESC enhancer starr_00040 Neighboring gene STARR-seq mESC enhancer starr_00043 Neighboring gene predicted gene, 57794 Neighboring gene transcription elongation factor A (SII) 1 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and catalytic mechanism of murine lysophospholipase I. Wang A, et al. J Biol Chem, 1997 May 9. PMID 9139730
  2. Regiospecificity and catalytic triad of lysophospholipase I. Wang A, et al. J Biol Chem, 1997 Aug 29. PMID 9268342
  3. Lyplal1 is dispensable for normal fat deposition in mice. Watson RA, et al. Dis Model Mech, 2017 Dec 19. PMID 29084768, Free PMC Article
  4. Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria. Speck SL, et al. Cell Rep, 2023 Nov 28. PMID 37925639, Free PMC Article
  5. Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. Toyoda T, et al. Biochim Biophys Acta, 1999 Feb 25. PMID 10064901

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
    Title: Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
  2. Lyplal1 is dispensable for normal mouse metabolic physiology.
    Title: Lyplal1 is dispensable for normal fat deposition in mice.
  3. Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.
    Title: Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
  4. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
    Title: Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Tcea1

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables palmitoyl-(protein) hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of aggrephagy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of aggrephagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein depalmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
acyl-protein thioesterase 1
Names
lysoPLA I
lysophopholipase 1
lysophospholipase I
palmitoyl-protein hydrolase
phospholipase 1a
NP_001342641.1
NP_032892.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355712.2 → NP_001342641.1  acyl-protein thioesterase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102311
    Consensus CDS
    CCDS87810.1
    UniProtKB/TrEMBL
    D3Z111, Q4FK51
    Related
    ENSMUSP00000111191.2, ENSMUST00000115529.8
    Conserved Domains (1) summary
    pfam02230
    Location:11 → 192
    Abhydrolase_2; Phospholipase/Carboxylesterase

  2. NM_008866.4 → NP_032892.1  acyl-protein thioesterase 1 isoform 1

    See identical proteins and their annotated locations for NP_032892.1

    Status: VALIDATED

    Source sequence(s)
    AC102311
    Consensus CDS
    CCDS14806.1
    UniProtKB/Swiss-Prot
    P97823, Q3TJZ0, Q7TPX1, Q8BWM6
    UniProtKB/TrEMBL
    Q4FK51
    Related
    ENSMUSP00000027036.5, ENSMUST00000027036.11
    Conserved Domains (2) summary
    COG0596
    Location:24 → 155
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam02230
    Location:11 → 226
    Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    4878046..4916958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97823.1 GenPept UniProtKB/Swiss-Prot:P97823

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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