U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Peg3 paternally expressed 3 [ Mus musculus (house mouse) ]

Gene ID: 18616, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Peg3provided by MGI
Official Full Name
paternally expressed 3provided by MGI
Primary source
MGI:MGI:104748
See related
Ensembl:ENSMUSG00000002265 AllianceGenome:MGI:104748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pw1; End4; ASF-1; Gcap4; Zfp102; mKIAA0287
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in autophagosome and nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Orthologous to human PEG3 (paternally expressed 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 77.8), limb E14.5 (RPKM 49.2) and 12 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Peg3 in Genome Data Viewer
Location:
7 A1; 7 3.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6706891..6733443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6703892..6730462, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger, imprinted 2 Neighboring gene zinc finger, imprinted 1 Neighboring gene STARR-seq mESC enhancer starr_17985 Neighboring gene Peg3 opposite strand Neighboring gene ubiquitin specific peptidase 29 Neighboring gene Tctex1 domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17987 Neighboring gene STARR-seq mESC enhancer starr_17989 Neighboring gene microRNA 3099

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transcription-driven DNA methylation setting on the mouse Peg3 locus. Bretz CL, et al. Epigenetics, 2017. PMID 28925797, Free PMC Article
  2. Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor. Ye A, et al. PLoS One, 2014. PMID 25265264, Free PMC Article
  3. DNA-Binding Motif of the Imprinted Transcription Factor PEG3. Lee S, et al. PLoS One, 2015. PMID 26692216, Free PMC Article
  4. Sex and Tissue Specificity of Peg3 Promoters. Perera BP, et al. PLoS One, 2016. PMID 27711129, Free PMC Article
  5. Embryonic deregulation of muscle stress signaling pathways leads to altered postnatal stem cell behavior and a failure in postnatal muscle growth. Nicolas N, et al. Dev Biol, 2005 May 15. PMID 15893971

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia-reperfusion injury via miR-1246/PEG3 signaling.
    Title: CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia‒reperfusion injury via miR-1246/PEG3 signaling.
  2. Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
    Title: Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
  3. Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.
    Title: Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.
  4. Allele-specific enhancer interaction at the Peg3 imprinted domain
    Title: Allele-specific enhancer interaction at the Peg3 imprinted domain.
  5. Study data show that Pw1/Peg3 regulates muscle fiber number determination during fetal development in a gene-dosage manner and regulates satellite cell metabolism in the adult.
    Title: The imprinted gene Pw1/Peg3 regulates skeletal muscle growth, satellite cell metabolic state, and self-renewal.
  6. Maternal deletion of Peg3-DMR (differentially methylated region) caused significant effects on the activity of the paternal allele, 2-fold increase of Peg3 and Usp29 throughout various tissues and different developmental stages. These effects were unidirectional with the maternal allele influencing the paternal one. These results suggest the presence of trans-allelic regulation associated with the Peg3-DMR.
    Title: Trans-allelic mutational effects at the Peg3 imprinted locus.
  7. YY1 is mainly involved in controlling the transcriptional levels, but not the DNA methylation, of the Peg3 domain.
    Title: YY1's role in the Peg3 imprinted domain.
  8. this study suggests that Peg3 may function as a direct transcriptional regulator for Oxtr expression that acts to moderate the milk letdown process.
    Title: Oxytocin receptor is regulated by Peg3.
  9. Data shows that loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers
    Title: Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers.
  10. Transcription driven by the alternative promoter U1 is required for oocyte-specific DNA methylation setting on the Peg3 locus.
    Title: Transcription-driven DNA methylation setting on the mouse Peg3 locus.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (7)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
paternally-expressed gene 3 protein
Names
granule cell antiserum positive 4
paternally expressed gene 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417064.1 → NP_001403993.1  paternally-expressed gene 3 protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157657
    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

  2. NM_001417065.1 → NP_001403994.1  paternally-expressed gene 3 protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157657
    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

  3. NM_001417066.1 → NP_001403995.1  paternally-expressed gene 3 protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157657
    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

  4. NM_001417068.1 → NP_001403997.1  paternally-expressed gene 3 protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157657
    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

  5. NM_001417070.1 → NP_001403999.1  paternally-expressed gene 3 protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC157657
    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53

  6. NM_001417071.1 → NP_001404000.1  paternally-expressed gene 3 protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC157657

  7. NM_001417072.1 → NP_001404001.1  paternally-expressed gene 3 protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC157657

  8. NM_008817.3 → NP_032843.2  paternally-expressed gene 3 protein isoform a

    See identical proteins and their annotated locations for NP_032843.2

    Status: VALIDATED

    Source sequence(s)
    AC157657
    Consensus CDS
    CCDS20783.1
    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
    UniProtKB/TrEMBL
    A0A5F8MPW9
    Related
    ENSMUSP00000050750.5, ENSMUST00000051209.11
    Conserved Domains (3) summary
    PHA03169
    Location:862 → 1080
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1147 → 1169
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6706891..6733443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242211.2 → XP_030098071.1  paternally-expressed gene 3 protein isoform X3

    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
    UniProtKB/TrEMBL
    A0A5F8MPW9
    Conserved Domains (3) summary
    PHA03169
    Location:862 → 1080
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1147 → 1169
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_017322030.3 → XP_017177519.1  paternally-expressed gene 3 protein isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPW9
    Conserved Domains (3) summary
    PHA03169
    Location:943 → 1151
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:408 → 428
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1218 → 1240
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_036152771.1 → XP_036008664.1  paternally-expressed gene 3 protein isoform X3

    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
    UniProtKB/TrEMBL
    A0A5F8MPW9
    Conserved Domains (3) summary
    PHA03169
    Location:862 → 1080
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1147 → 1169
    zf-C2H2; Zinc finger, C2H2 type

  4. XM_036152776.1 → XP_036008669.1  paternally-expressed gene 3 protein isoform X4

    UniProtKB/TrEMBL
    Q0P5Y8
    Conserved Domains (3) summary
    PHA03169
    Location:718 → 936
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1003 → 1025
    zf-C2H2; Zinc finger, C2H2 type

  5. XM_030242212.1 → XP_030098072.1  paternally-expressed gene 3 protein isoform X3

    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
    UniProtKB/TrEMBL
    A0A5F8MPW9
    Conserved Domains (3) summary
    PHA03169
    Location:862 → 1080
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1147 → 1169
    zf-C2H2; Zinc finger, C2H2 type

  6. XM_036152774.1 → XP_036008667.1  paternally-expressed gene 3 protein isoform X3

    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
    UniProtKB/TrEMBL
    A0A5F8MPW9
    Conserved Domains (3) summary
    PHA03169
    Location:862 → 1080
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1147 → 1169
    zf-C2H2; Zinc finger, C2H2 type

  7. XM_036152773.1 → XP_036008666.1  paternally-expressed gene 3 protein isoform X3

    UniProtKB/Swiss-Prot
    O54978, Q3TQ69, Q3URU2, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
    UniProtKB/TrEMBL
    A0A5F8MPW9
    Conserved Domains (3) summary
    PHA03169
    Location:862 → 1080
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1147 → 1169
    zf-C2H2; Zinc finger, C2H2 type

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001010988.1: Suppressed sequence

    Description
    NM_001010988.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URU2.1 GenPept UniProtKB/Swiss-Prot:Q3URU2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools