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Pde9a phosphodiesterase 9A [ Mus musculus (house mouse) ]

Gene ID: 18585, updated on 2-Nov-2024

Summary

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Official Symbol
Pde9aprovided by MGI
Official Full Name
phosphodiesterase 9Aprovided by MGI
Primary source
MGI:MGI:1277179
See related
Ensembl:ENSMUSG00000041119 AllianceGenome:MGI:1277179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PDE9A1
Summary
Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process and positive regulation of cardiac muscle hypertrophy. Predicted to be located in several cellular components, including nucleoplasm; perikaryon; and sarcolemma. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 62.7), large intestine adult (RPKM 61.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Pde9a in Genome Data Viewer
Location:
17 B1; 17 16.23 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31605079..31695284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31386105..31476309)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31649222-31649405 Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene WD repeat domain 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9. Ceddia RP, et al. Diabetes, 2021 Dec. PMID 34620617, Free PMC Article
  2. PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice. Kolb TM, et al. Physiol Rep, 2021 Sep. PMID 34569183, Free PMC Article
  3. The effect of phosphodiesterase inhibitors on the extinction of cocaine-induced conditioned place preference in mice. Liddie S, et al. J Psychopharmacol, 2012 Oct. PMID 22596207
  4. Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span. Patel NS, et al. Neurobiol Aging, 2018 May. PMID 29505961, Free PMC Article
  5. PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Dhingra A, et al. Front Mol Neurosci, 2014. PMID 25018695, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice.
    Title: PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice.
  2. Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.
    Title: Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.
  3. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.
    Title: Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.
  4. Brain PDE9 is localized to preferentially regulate nuclear- and membrane-proximal pools of cGMP, and its function likely changes across the life span.
    Title: Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span.
  5. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.
    Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
  6. Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity).
    Title: The effect of phosphodiesterase inhibitors on the extinction of cocaine-induced conditioned place preference in mice.
  7. This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes.
    Title: Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cGMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
NP_001157220.1
NP_001397616.1
NP_001397617.1
NP_001397618.1
NP_001397619.1
NP_001397620.1
NP_032830.3
XP_036016291.1
XP_036016292.1
XP_036016293.1
XP_036016294.1
XP_036016295.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163748.2 → NP_001157220.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1

    See identical proteins and their annotated locations for NP_001157220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154652, AC166172
    Consensus CDS
    CCDS28605.1
    UniProtKB/Swiss-Prot
    O70628
    UniProtKB/TrEMBL
    Q8BSU4
    Related
    ENSMUSP00000117611.2, ENSMUST00000127929.8
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001410687.1 → NP_001397616.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154652, AC166172

  3. NM_001410688.1 → NP_001397617.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154652, AC166172
    Related
    ENSMUSP00000158101.2, ENSMUST00000235719.2

  4. NM_001410689.1 → NP_001397618.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166172
    UniProtKB/TrEMBL
    D3Z408

  5. NM_001410690.1 → NP_001397619.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166172
    UniProtKB/TrEMBL
    D3Z408
    Related
    ENSMUSP00000116724.3, ENSMUST00000136384.9

  6. NM_001410691.1 → NP_001397620.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154652, AC166172
    UniProtKB/TrEMBL
    D3Z408
    Related
    ENSMUSP00000157420.2, ENSMUST00000236454.2

  7. NM_008804.5 → NP_032830.3  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1

    See identical proteins and their annotated locations for NP_032830.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154652, AC166172
    Consensus CDS
    CCDS28605.1
    UniProtKB/Swiss-Prot
    O70628
    UniProtKB/TrEMBL
    Q8BSU4
    Related
    ENSMUSP00000038005.6, ENSMUST00000047168.13
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. NR_177107.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154652, AC166172

  2. NR_177108.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154652, AC166172
    Related
    ENSMUST00000124902.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31605079..31695284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160399.1 → XP_036016292.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    UniProtKB/TrEMBL
    A0A494BAJ0
    Related
    ENSMUSP00000158058.2, ENSMUST00000235639.2
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_036160398.1 → XP_036016291.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    UniProtKB/TrEMBL
    A0A494BAJ0
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_036160401.1 → XP_036016294.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    UniProtKB/TrEMBL
    A0A494BBD2
    Conserved Domains (1) summary
    pfam00233
    Location:103 → 331
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_036160400.1 → XP_036016293.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    UniProtKB/TrEMBL
    A0A494BBD2
    Conserved Domains (1) summary
    pfam00233
    Location:103 → 331
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_036160402.1 → XP_036016295.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    UniProtKB/TrEMBL
    A0A494BBD2
    Conserved Domains (1) summary
    pfam00233
    Location:103 → 331
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70628.1 GenPept UniProtKB/Swiss-Prot:O70628

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