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ocr-1 ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185101, updated on 2-Nov-2024

Summary

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Official Symbol
ocr-1
Official Full Name
ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein
Primary source
WormBase:WBGene00003838
Locus tag
CELE_F28H7.10
See related
AllianceGenome:WB:WBGene00003838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables temperature-gated cation channel activity. Involved in heat acclimation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ADLL; ADLR; AWAL; and AWAR. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; congenital stationary night blindness; hyperparathyroidism; keratosis (multiple); and migraine with aura. Orthologous to several human genes including TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ocr-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
14
Sequence:
Chromosome: V; NC_003283.11 (10764366..10768590)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Receptor L-domain domain-containing protein Neighboring gene CRAL-TRIO domain-containing protein F28H7.8 Neighboring gene Serpentine receptor class epsilon-6 Neighboring gene ncRNA Neighboring gene PNPLA domain-containing protein Neighboring gene Proteasome subunit alpha type-2 Neighboring gene SGS domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation. Ohnishi K, et al. Sci Rep, 2020 Oct 29. PMID 33122746, Free PMC Article
  2. Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans. Okahata M, et al. Sci Adv, 2019 Feb. PMID 30775442, Free PMC Article
  3. A specific subset of transient receptor potential vanilloid-type channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release. Jose AM, et al. Genetics, 2007 Jan. PMID 17057248, Free PMC Article
  4. Function and regulation of TRP family channels in C. elegans. Xiao R, et al. Pflugers Arch, 2009 Sep. PMID 19421772, Free PMC Article
  5. Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Tobin DM, et al. Neuron, 2002 Jul 18. PMID 12160748

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables temperature-gated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heat acclimation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heat acclimation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein
NP_001041107.1
  • Confirmed by transcript evidence
NP_001335506.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10764366..10768590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348583.2 → NP_001335506.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDR9
    Conserved Domains (3) summary
    TIGR00870
    Location:154 → 756
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:200 → 266
    ANK; ANK repeat [structural motif]
    pfam05672
    Location:781 → 849
    MAP7; MAP7 (E-MAP-115) family

  2. NM_001047642.1 → NP_001041107.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1NZ21
Nucleotide Protein
Heading Accession and Version

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