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DUSP8 dual specificity phosphatase 8 [ Homo sapiens (human) ]

Gene ID: 1850, updated on 5-Mar-2024

Summary

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Official Symbol
DUSP8provided by HGNC
Official Full Name
dual specificity phosphatase 8provided by HGNC
Primary source
HGNC:HGNC:3074
See related
Ensembl:ENSG00000184545 MIM:602038; AllianceGenome:HGNC:3074
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB5; HVH8; HVH-5; C11orf81
Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 9.1), colon (RPKM 3.4) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See DUSP8 in Genome Data Viewer
Location:
11p15.5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1554051..1572848, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1635383..1654159, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1575281..1593501, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1520757-1521279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1528327-1529160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1529995-1530826 Neighboring gene uncharacterized LOC124902607 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534293-1534794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534795-1535294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541250-1541750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541751-1542251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1547587-1548086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1553250-1553750 Neighboring gene uncharacterized LOC124902608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1576597-1577394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1578991-1579788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1580587-1581382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1588223-1589161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1589162-1590100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1590101-1591039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1592555-1593102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1593651-1594196 Neighboring gene KRTAP5-1/KRTAP5-2 antisense RNA 1 Neighboring gene keratin associated protein 5-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1617579-1618152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1618727-1619300 Neighboring gene keratin associated protein 5-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways. Zhang H, et al. J Investig Med, 2022 Jun. PMID 35428675
  2. Investigation of DUSP8 and CALCA in alcohol dependence. Hink RL, et al. Addict Biol, 2003 Sep. PMID 13129832
  3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans. Baumann P, et al. Brain Behav, 2021 Jan. PMID 33131190, Free PMC Article
  4. Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite. Cotsiki M, et al. Cell Signal, 2012 Mar. PMID 22100391
  5. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. Nesbit MA, et al. Genomics, 1997 Jun 1. PMID 9192849

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha.
    Title: DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α.
  2. Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways.
    Title: Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways.
  3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
    Title: Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
  4. The phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation.
    Title: Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.
  5. Because this variant of hVH-5 lacked intronic sequences in its genomic structure, we suggest it might be a processed pseudogene of hVH-5.
    Title: Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2.
  6. DUSP8 is genetically linked to alcohol dependence and was found on chromosome 11p15.5
    Title: Investigation of DUSP8 and CALCA in alcohol dependence.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42476, FLJ42958

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 8
Names
H1 phosphatase, vaccinia virus homolog
dual specificity protein phosphatase hVH-5
serine/threonine specific protein phosphatase
NP_004411.2
XP_011518234.1
XP_011518235.1
XP_047282469.1
XP_054184836.1
XP_054184837.1
XP_054184838.1
XP_054185959.1
XP_054185960.1
XP_054185961.1
XP_054189085.1
XP_054189086.1
XP_054189087.1
XP_054223912.1
XP_054223913.1
XP_054223914.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004420.3 → NP_004411.2  dual specificity protein phosphatase 8

    See identical proteins and their annotated locations for NP_004411.2

    Status: REVIEWED

    Source sequence(s)
    AK124467, AP006285, BC045110, BU740880, U27193
    Consensus CDS
    CCDS7724.1
    UniProtKB/Swiss-Prot
    Q13202, Q86SS8
    Related
    ENSP00000380530.3, ENST00000397374.8
    Conserved Domains (2) summary
    cd00127
    Location:160 → 297
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1554051..1572848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519933.3 → XP_011518235.1  dual specificity protein phosphatase 8 isoform X1

    See identical proteins and their annotated locations for XP_011518235.1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8
    Related
    ENSP00000329539.4, ENST00000331588.4
    Conserved Domains (2) summary
    cd00127
    Location:160 → 297
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

  2. XM_047426513.1 → XP_047282469.1  dual specificity protein phosphatase 8 isoform X2

  3. XM_011519932.3 → XP_011518234.1  dual specificity protein phosphatase 8 isoform X1

    See identical proteins and their annotated locations for XP_011518234.1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8
    Conserved Domains (2) summary
    cd00127
    Location:160 → 297
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791792.1 Reference GRCh38.p14 PATCHES

    Range
    294027..312824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333111.1 → XP_054189086.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

  2. XM_054333112.1 → XP_054189087.1  dual specificity protein phosphatase 8 isoform X2

  3. XM_054333110.1 → XP_054189085.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187584.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    36288..55085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328862.1 → XP_054184837.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

  2. XM_054328863.1 → XP_054184838.1  dual specificity protein phosphatase 8 isoform X2

  3. XM_054328861.1 → XP_054184836.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    30578..49375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329985.1 → XP_054185960.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

  2. XM_054329986.1 → XP_054185961.1  dual specificity protein phosphatase 8 isoform X2

  3. XM_054329984.1 → XP_054185959.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1635383..1654159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367938.1 → XP_054223913.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8

  2. XM_054367939.1 → XP_054223914.1  dual specificity protein phosphatase 8 isoform X2

  3. XM_054367937.1 → XP_054223912.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q13202, Q86SS8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13202.2 GenPept UniProtKB/Swiss-Prot:Q13202

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