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AGTR1 angiotensin II receptor type 1 [ Homo sapiens (human) ]

Gene ID: 185, updated on 11-Apr-2024

Summary

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Official Symbol
AGTR1provided by HGNC
Official Full Name
angiotensin II receptor type 1provided by HGNC
Primary source
HGNC:HGNC:336
See related
Ensembl:ENSG00000144891 MIM:106165; AllianceGenome:HGNC:336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT1; AG2S; AT1B; AT1R; ATR1; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Expression
Biased expression in placenta (RPKM 58.2), fat (RPKM 27.9) and 9 other tissues See more
Orthologs
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Genomic context

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See AGTR1 in Genome Data Viewer
Location:
3q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (148697903..148743003)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (151448936..151494033)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148415690..148460790)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374150 Neighboring gene HNF1 motif-containing MPRA enhancer 244 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:148360892-148362091 Neighboring gene RPL38 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:148472851-148473352 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:148498709-148498859 Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients. Luo JY, et al. BMC Cardiovasc Disord, 2023 Jun 3. PMID 37270600, Free PMC Article
  2. Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men. Rocha HNM, et al. Braz J Med Biol Res, 2023. PMID 36995873, Free PMC Article
  3. Association between AT1 receptor gene polymorphism and left ventricular hypertrophy and arterial stiffness in essential hypertension patients: a prospective cohort study. Ou H, et al. BMC Cardiovasc Disord, 2022 Dec 28. PMID 36577936, Free PMC Article
  4. AT1 receptor autoantibodies mediate effects of metabolic syndrome on dopaminergic vulnerability. Pedrosa MA, et al. Brain Behav Immun, 2023 Feb. PMID 36535607
  5. ATR1 Angiotensin II Receptor Reduces Hemoglobin S Polymerization, Phosphatidylserine Exposure, and Increases Deformability of Sickle Cell Disease Erythrocytes. Guimarães-Nobre CC, et al. Cell Biochem Biophys, 2022 Dec. PMID 36175813

See all (977) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
    Title: Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
  2. Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis.
    Title: Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis.
  3. Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
    Title: Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
  4. Interactions between AT1R and GRKs: the determinants for activation of signaling pathways involved in blood pressure regulation.
    Title: Interactions between AT1R and GRKs: the determinants for activation of signaling pathways involved in blood pressure regulation.
  5. POLYMORPHISM OF ACE AND AT2R1 GENES AS A GENETIC BACKGROUND FOR DIFFERENT TYPES OF ENCEPHALOPATHIES.
    Title: POLYMORPHISM OF ACE AND AT2R1 GENES AS A GENETIC BACKGROUND FOR DIFFERENT TYPES OF ENCEPHALOPATHIES.
  6. Association of the rs5186 polymorphism of the AGTR1 gene with decreased eGFR in patients with type 2 diabetes from Mexico City.
    Title: Association of the rs5186 polymorphism of the AGTR1 gene with decreased eGFR in patients with type 2 diabetes from Mexico City.
  7. The role of EGFR in vascular AT1R signaling: From cellular mechanisms to systemic relevance.
    Title: The role of EGFR in vascular AT1R signaling: From cellular mechanisms to systemic relevance.
  8. Immunolocalization of the AT-1R Ang II Receptor in Human Kidney Cancer.
    Title: Immunolocalization of the AT-1R Ang II Receptor in Human Kidney Cancer.
  9. Association between AGTR1 (c.1166 A>C) Polymorphisms and Kidney Injury in Hypertension.
    Title: Association between AGTR1 (c.1166 A>C) Polymorphisms and Kidney Injury in Hypertension.
  10. Transcriptomic evidence of hypothalamus for maternal fructose exposure induced offspring hypertension through AT1R/TLR4 pathway.
    Title: Transcriptomic evidence of hypothalamus for maternal fructose exposure induced offspring hypertension through AT1R/TLR4 pathway.
Submit: New GeneRIF Correction See all GeneRIFs (670)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Essential hypertension, genetic
MedGen: CN305331 OMIM: 145500 GeneReviews: Not available
Compare labs
Renal tubular dysgenesis of genetic origin
MedGen: C5681536 OMIM: 267430 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables angiotensin type I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables angiotensin type I receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables angiotensin type I receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables angiotensin type II receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables bradykinin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blood vessel diameter maintenance IC
Inferred by Curator
more info
 PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in low-density lipoprotein particle remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin IC
Inferred by Curator
more info
 PubMed 
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in phospholipase C-activating angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of CoA-transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of inflammatory response IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of renal sodium excretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure by renin-angiotensin IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of vasoconstriction IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vasoconstriction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in renin-angiotensin regulation of aldosterone production NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in symbiont entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
type-1 angiotensin II receptor
Names
AT1 receptor
type-1B angiotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008468.2 RefSeqGene

    Range
    5002..50102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000685.5 → NP_000676.1  type-1 angiotensin II receptor

    See identical proteins and their annotated locations for NP_000676.1

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Related
    ENSP00000273430.3, ENST00000349243.8
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001382736.1 → NP_001369665.1  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Related
    ENSP00000385612.2, ENST00000404754.2
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001382737.1 → NP_001369666.1  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_004835.5 → NP_004826.6  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Related
    ENSP00000398832.4, ENST00000418473.7
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_009585.4 → NP_033611.1  type-1 angiotensin II receptor

    See identical proteins and their annotated locations for NP_033611.1

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Related
    ENSP00000419422.1, ENST00000497524.5
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. NM_031850.4 → NP_114038.5  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. NM_032049.4 → NP_114438.3  type-1 angiotensin II receptor

    Status: REVIEWED

    Source sequence(s)
    AC024897
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556, Q13725, Q8TBK4
    UniProtKB/TrEMBL
    D3DNG9, Q53YY0, Q6NUP5
    Related
    ENSP00000385641.3, ENST00000402260.2
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    148697903..148743003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    151448936..151494033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30556.1 GenPept UniProtKB/Swiss-Prot:P30556

Gene LinkOut

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