Palm paralemmin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Palmprovided by MGI
Official Full Name: paralemminprovided by MGI
Primary source: MGI:MGI:1261814
See related: Ensembl:ENSMUSG00000035863 AllianceGenome:MGI:1261814
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables D3 dopamine receptor binding activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of dendritic spine development; and positive regulation of filopodium assembly. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and regulation of cell shape. Located in several cellular components, including filopodium; neuron spine; and postsynaptic density. Is expressed in several structures, including eye; liver; nasal epithelium; nervous system; and renal cortex. Orthologous to human PALM (paralemmin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 57.4), adrenal adult (RPKM 54.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79629406..79656749)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79793572..79820915)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paralemmin-1 is expressed in normal and tumor-derived lymphatic endothelial cells. It represses cell migration and delays the formation of tube-like lymphatic structures by modulating cell adhesion, filopodia formation and plasma membrane blebbing.
Title: Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis.
Expression of Palm in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
report that palmitoylation-deficient (Palm(-/-)) mice carrying two Cys to Thr and Ser mutations in the opsin gene displayed profound light-induced retinal degeneration that first involved rod and then cone cells.
Title: Palmitoylation stabilizes unliganded rod opsin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Palm (e-PCR), detects polymorphism
- UniSTS:525928

Y14771 (e-PCR)
- UniSTS:163479

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D3 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to electrical stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse maturation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in neuron spine	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: paralemmin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161747.1 → NP_001155219.1 paralemmin-1 isoform 2

See identical proteins and their annotated locations for NP_001155219.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC151828, AK082163, AK162411

Consensus CDS

CCDS48621.1

UniProtKB/TrEMBL

Q542N8, Q91WF5

Related

ENSMUSP00000101018.3, ENSMUST00000105379.3

Conserved Domains (3) summary

cd14458
Location:10 → 53

DP_DD; coiled coil [structural motif]

pfam03285
Location:71 → 339

Paralemmin; Paralemmin

cl07405
Location:10 → 53

DP_DD; Dimerization domain of DP
NM_001428706.1 → NP_001415635.1 paralemmin-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC124407
NM_001428707.1 → NP_001415636.1 paralemmin-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC124407
NM_023128.4 → NP_075617.3 paralemmin-1 isoform 1

See identical proteins and their annotated locations for NP_075617.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC151828, AK037044, AK082163

Consensus CDS

CCDS23991.1

UniProtKB/Swiss-Prot

Q9Z0P3, Q9Z0P4

UniProtKB/TrEMBL

Q8CB16

Related

ENSMUSP00000040596.7, ENSMUST00000046945.13

Conserved Domains (3) summary

cd14458
Location:10 → 53

DP_DD; coiled coil [structural motif]

pfam03285
Location:71 → 383

Paralemmin; Paralemmin

cl07405
Location:10 → 53

DP_DD; Dimerization domain of DP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79629406..79656749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313830.2 → XP_017169319.1 paralemmin-1 isoform X1

UniProtKB/TrEMBL

Q6ZQE7

Conserved Domains (1) summary

pfam03285
Location:2 → 314

Paralemmin