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Ovol1 ovo like zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 18426, updated on 18-Sep-2024

Summary

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Official Symbol
Ovol1provided by MGI
Official Full Name
ovo like zinc finger 1provided by MGI
Primary source
MGI:MGI:1330290
See related
Ensembl:ENSMUSG00000024922 AllianceGenome:MGI:1330290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ovo1; movo1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of meiotic cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 17.2), small intestine adult (RPKM 13.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Ovol1 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5599165..5610603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5549137..5560575, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8730 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5491370-5491523 Neighboring gene cofilin 1, non-muscle Neighboring gene sorting nexin 32 Neighboring gene STARR-positive B cell enhancer ABC_E1208 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component like Neighboring gene predicted gene, 31166 Neighboring gene adaptor-related protein complex 5, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_45393 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5601776-5601959 Neighboring gene ribonuclease H2, subunit C Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation. Dragan M, et al. J Invest Dermatol, 2022 Mar. PMID 34461129, Free PMC Article
  2. OVO homolog-like 1, a target gene of the Wnt/β-catenin pathway, controls hair follicle neogenesis. Shin SH, et al. J Invest Dermatol, 2014 Mar. PMID 24126846
  3. OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia. Sun P, et al. J Invest Dermatol, 2021 Jun. PMID 33333123, Free PMC Article
  4. OVO homologue-like 1 promotes osteoblast differentiation through BMP2 expression. Min HY, et al. J Cell Physiol, 2019 Jul. PMID 30523637
  5. Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis. Bak SS, et al. Exp Dermatol, 2015 Jul. PMID 25827793

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.
    Title: Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.
  2. OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia.
    Title: OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia.
  3. that OVOL1 function as an important regulator of osteoblast differentiation by inducing BMP2 expression in MC3T3-E1 cells
    Title: OVO homologue-like 1 promotes osteoblast differentiation through BMP2 expression.
  4. OVOL1-regulated Fst and SFRP1 affect hair inductive potency of neonatal dermal cells.
    Title: Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis.
  5. OVOL1 of mouse neonatal dermal cells has a critical role in hair follicle neogenesis.
    Title: OVO homolog-like 1, a target gene of the Wnt/β-catenin pathway, controls hair follicle neogenesis.
  6. The LEF1/beta -catenin complex activates movo1
    Title: The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.
  7. regulates pachytene progression of male germ cells, Id2 is target
    Title: Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
  8. Ovol1 mutant mice suffered perinatal lethality accompanied by kidney epithelial cysts of embryonic onset and delayed skin barrier acquisition; Ovol2 is a downstream target of Ovol1.
    Title: Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epidermis development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germline cell cycle switching, mitotic to meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of keratinocyte proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of meiotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of keratinocyte proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of meiotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative transcription factor Ovo-like 1
Names
OVO homolog-like 1
mOvo1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019935.3 → NP_064319.1  putative transcription factor Ovo-like 1

    See identical proteins and their annotated locations for NP_064319.1

    Status: VALIDATED

    Source sequence(s)
    AK028577
    Consensus CDS
    CCDS29469.1
    UniProtKB/Swiss-Prot
    Q545S2, Q9WTJ2
    UniProtKB/TrEMBL
    Q3UME7
    Related
    ENSMUSP00000025861.2, ENSMUST00000025861.3
    Conserved Domains (3) summary
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:118 → 138
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:160 → 185
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5599165..5610603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531676.5 → XP_006531739.1  putative transcription factor Ovo-like 1 isoform X2

    See identical proteins and their annotated locations for XP_006531739.1

    Conserved Domains (2) summary
    sd00017
    Location:58 → 78
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:98 → 123
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011248605.4 → XP_011246907.1  putative transcription factor Ovo-like 1 isoform X1

    UniProtKB/TrEMBL
    Q3UME7
    Conserved Domains (3) summary
    sd00017
    Location:89 → 109
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:87 → 107
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:129 → 154
    zf-H2C2_2; Zinc-finger double domain

  3. XM_006531675.5 → XP_006531738.1  putative transcription factor Ovo-like 1 isoform X2

    See identical proteins and their annotated locations for XP_006531738.1

    Conserved Domains (2) summary
    sd00017
    Location:58 → 78
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:98 → 123
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011248606.4 → XP_011246908.1  putative transcription factor Ovo-like 1 isoform X2

    See identical proteins and their annotated locations for XP_011246908.1

    Conserved Domains (2) summary
    sd00017
    Location:58 → 78
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:98 → 123
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTJ2.1 GenPept UniProtKB/Swiss-Prot:Q9WTJ2

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