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DRG2 developmentally regulated GTP binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1819, updated on 5-Mar-2024

Summary

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Official Symbol
DRG2provided by HGNC
Official Full Name
developmentally regulated GTP binding protein 2provided by HGNC
Primary source
HGNC:HGNC:3030
See related
Ensembl:ENSG00000108591 MIM:602986; AllianceGenome:HGNC:3030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18087948..18107969)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18034778..18054782)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17991262..18011283)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene Sharpr-MPRA regulatory region 6800 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17925691-17925854 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11823 Neighboring gene GID complex subunit 4 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991145-17991646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991647-17992146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18010366-18011013 Neighboring gene uncharacterized LOC105371566 Neighboring gene myosin XVA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18038431-18039424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18039425-18040418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18045565-18046530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18046531-18047495 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124903944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18053522-18054022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18056260-18056783

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis. Kim SC, et al. Investig Clin Urol, 2021 Jul. PMID 34190439, Free PMC Article
  2. DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization. Mani M, et al. Biochim Biophys Acta Mol Cell Res, 2019 Sep. PMID 31199931
  3. DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells. Dang T, et al. Mol Cells, 2018 Dec 31. PMID 30453731, Free PMC Article
  4. Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis. Song H, et al. J Biochem, 2004 Mar. PMID 15113831
  5. Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval. Vlangos CN, et al. Cytogenet Cell Genet, 2000. PMID 10828610

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
    Title: Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
  2. Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
    Title: Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
  3. Developmentally regulated GTPases: structure, function and roles in disease.
    Title: Developmentally regulated GTPases: structure, function and roles in disease.
  4. DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
    Title: DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
  5. Knockdown of DRG2 in HeLa cells treated with epidermal growth factor (EGF) affects microtubule dynamics, perinuclear Golgi stacking, and cell migration.
    Title: DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization.
  6. Using immunoprecipitation, authors show that DRG2 interacts with tau, which regulates microtubule polymerization. Collectively, these data demonstrate that DRG2 may aid in affecting microtubule dynamics in HeLa cells.
    Title: DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
  7. Results show that the SNP (rs2257609 C>T) located in the intron region of SLC5A10 variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2. It is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients.
    Title: Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.
  8. Taken together, our data demonstrate that DRG2 acts as a regulator of mitochondrial fission by controlling the expression of Drp1.
    Title: Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.
  9. Authors observed that knockdown of DRG2 in HeLa cells affected growth in a wound-healing assay, and tumorigenicity in nude mice xenografts.
    Title: DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.
  10. Results demonstrate that DRG2 is an endosomal protein and a key regulator of Rab5 deactivation and Tfn recycling.
    Title: Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
developmentally-regulated GTP-binding protein 2
Names
TRAFAC GTPase DRG2
translation factor GTPase DRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330144.2 → NP_001317073.1  developmentally-regulated GTP-binding protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC087164
    Consensus CDS
    CCDS82082.1
    UniProtKB/TrEMBL
    A8MZF9
    Related
    ENSP00000379076.4, ENST00000395726.8
    Conserved Domains (4) summary
    cd01896
    Location:63 → 295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1 → 331
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl00155
    Location:289 → 331
    UBQ; Ubiquitin-like proteins
    cl21455
    Location:3 → 119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001388.5 → NP_001379.1  developmentally-regulated GTP-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001379.1

    Status: REVIEWED

    Source sequence(s)
    BC000493, DA602486, X80754
    Consensus CDS
    CCDS11191.1
    UniProtKB/Swiss-Prot
    B2R8G5, P55039, Q53Y50, Q9BWB2
    Related
    ENSP00000225729.3, ENST00000225729.8
    Conserved Domains (4) summary
    cd01666
    Location:289 → 363
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63 → 295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1 → 364
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3 → 119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18087948..18107969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256499.4 → XP_005256556.1  developmentally-regulated GTP-binding protein 2 isoform X1

    Conserved Domains (4) summary
    cd01666
    Location:289 → 384
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63 → 295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1 → 385
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3 → 119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_011523704.3 → XP_011522006.1  developmentally-regulated GTP-binding protein 2 isoform X2

    Conserved Domains (4) summary
    cd01896
    Location:63 → 295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1 → 352
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl00155
    Location:289 → 352
    UBQ; Ubiquitin-like proteins
    cl21455
    Location:3 → 119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_005256500.3 → XP_005256557.1  developmentally-regulated GTP-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd01666
    Location:208 → 303
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:1 → 214
    DRG; Developmentally Regulated GTP-binding protein (DRG)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    18034778..18054782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315305.1 → XP_054171280.1  developmentally-regulated GTP-binding protein 2 isoform X1

  2. XM_054315306.1 → XP_054171281.1  developmentally-regulated GTP-binding protein 2 isoform X2

  3. XM_054315307.1 → XP_054171282.1  developmentally-regulated GTP-binding protein 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55039.1 GenPept UniProtKB/Swiss-Prot:P55039

Gene LinkOut

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