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his-24 Histone 24 [ Caenorhabditis elegans ]

Gene ID: 181545, updated on 19-Jun-2024

Summary

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Gene symbol
his-24
Gene description
Histone 24
Locus tag
CELE_M163.3
See related
AllianceGenome:WB:WBGene00001898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation; negative regulation of DNA recombination; and nucleosome positioning. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including germ line; gonad; head; intestine; and pharynx. Orthologous to human H1-0 (H1.0 linker histone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See his-24 in Genome Data Viewer
Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_003284.9 (14490094..14491119)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Linker histones: novel insights into structure-specific recognition of the nucleosome. Cutter AR, et al. Biochem Cell Biol, 2017 Apr. PMID 28177778, Free PMC Article
  2. A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans. Jedrusik MA, et al. Development, 2001 Apr. PMID 11245572
  3. Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression. Studencka M, et al. Mol Cell Biol, 2012 Jan. PMID 22083954, Free PMC Article
  4. Imaging embryonic development in Caenorhabditis elegans. Mohler WA, et al. Cold Spring Harb Protoc, 2010 Mar. PMID 20194475
  5. Interplay between histone deacetylase SIR-2, linker histone H1 and histone methyltransferases in heterochromatin formation. Wirth M, et al. Epigenetics, 2009 Aug 16. PMID 19736527

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans H1 variant his-24, hpl-1, and hpl-2 coregulate the expression of genes linked to immune response.
    Title: Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables H3K27me3 modified histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone 24
NP_510410.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14490094..14491119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078009.7 → NP_510410.1  Histone 24 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510410.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10771, Q93901
    Conserved Domains (1) summary
    pfam00538
    Location:38 → 112
    Linker_histone; linker histone H1 and H5 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10771.4

Gene LinkOut

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