U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sym-4 WD repeat-containing protein 44 [ Caenorhabditis elegans ]

Gene ID: 181527, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
sym-4
Official Full Name
WD repeat-containing protein 44
Primary source
WormBase:WBGene00006369
Locus tag
CELE_R03E1.1
See related
AllianceGenome:WB:WBGene00006369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Is expressed in several structures, including anal depressor muscle; coelomocyte; nervous system; rectum; and reproductive system. Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sym-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (14164640..14169619, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene Vacuolar H ATPase Neighboring gene putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Neighboring gene FAR-17a/AIG1-like protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis. Kelley M, et al. Elife, 2015 Mar 23. PMID 25798732, Free PMC Article
  2. Effectors of anterior morphogenesis in C. elegans embryos. Balasubramaniam B, et al. Biol Open, 2023 Jul 15. PMID 37345480, Free PMC Article
  3. The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans. Yochem J, et al. Genetics, 2004 Nov. PMID 15579686, Free PMC Article
  4. Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans. Davies AG, et al. Genetics, 1999 Sep. PMID 10471705, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

General protein information

Go to the top of the page Help
Preferred Names
WD repeat-containing protein 44
NP_510361.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14164640..14169619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077960.8 → NP_510361.1  WD repeat-containing protein 44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510361.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEV4
    Conserved Domains (3) summary
    COG2319
    Location:603 → 919
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:721 → 755
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:614 → 920
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools