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Npas1 neuronal PAS domain protein 1 [ Mus musculus (house mouse) ]

Gene ID: 18142, updated on 2-Nov-2024

Summary

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Official Symbol
Npas1provided by MGI
Official Full Name
neuronal PAS domain protein 1provided by MGI
Primary source
MGI:MGI:109205
See related
Ensembl:ENSMUSG00000001988 AllianceGenome:MGI:109205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOP5; bHLHe11
Summary
Enables protein heterodimerization activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within maternal behavior; negative regulation of transcription by RNA polymerase II; and startle response. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; lung; and nervous system. Orthologous to human NPAS1 (neuronal PAS domain protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 4.5), cortex adult (RPKM 2.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Npas1 in Genome Data Viewer
Location:
7 A2; 7 9.14 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16189643..16210741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16455721..16476822, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18133 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E347 Neighboring gene transmembrane protein 160 Neighboring gene nuclear encoded rRNA 5S 151 Neighboring gene STARR-positive B cell enhancer ABC_E10425 Neighboring gene Rho GTPase activating protein 35 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 17981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons.
    Title: Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons.
  2. Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
    Title: Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
  3. Parvalbumin(+) and Npas1(+) Pallidal Neurons Have Distinct Circuit Topology and Function.
    Title: Parvalbumin(+) and Npas1(+) Pallidal Neurons Have Distinct Circuit Topology and Function.
  4. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions.
    Title: Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.
  5. Npas1-expressing neurons and parvalbumin-expressing neurons are two distinct functional classes of globus pallidus neurons.
    Title: Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.
  6. The result of this study provided the evidence that NPAS1 represses the generation of specific subtypes of cortical interneurons.
    Title: NPAS1 represses the generation of specific subtypes of cortical interneurons.
  7. These results suggest that NPAS1 plays a novel and important role in regulating TH level of dopaminergic neurons in the ventral midbrain during development.
    Title: Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons.
  8. a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
    Title: Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
  9. Npas1 can regulate myofibroblast distribution, branching morphogenesis, and neuroendocrine cell differentiation in murine embryonic lung.
    Title: NPAS1 regulates branching morphogenesis in embryonic lung.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within maternal behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within startle response IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronal PAS domain-containing protein 1
Names
neuronal PAS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417027.1 → NP_001403956.1  neuronal PAS domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164880

  2. NM_008718.2 → NP_032744.1  neuronal PAS domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_032744.1

    Status: VALIDATED

    Source sequence(s)
    AC164880, BC137863, BY279348
    Consensus CDS
    CCDS20850.1
    UniProtKB/Swiss-Prot
    P97459
    UniProtKB/TrEMBL
    A2RSH6
    Related
    ENSMUSP00000002053.9, ENSMUST00000002053.9
    Conserved Domains (3) summary
    smart00091
    Location:141 → 198
    PAS; PAS domain
    pfam08447
    Location:316 → 387
    PAS_3; PAS fold
    cd19731
    Location:43 → 116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16189643..16210741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152765.1 → XP_036008658.1  neuronal PAS domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    smart00091
    Location:141 → 198
    PAS; PAS domain
    cd19731
    Location:43 → 116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

  2. XM_017322022.3 → XP_017177511.1  neuronal PAS domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    smart00091
    Location:141 → 198
    PAS; PAS domain
    cd19731
    Location:43 → 116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

  3. XM_017322021.3 → XP_017177510.1  neuronal PAS domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P97459
    UniProtKB/TrEMBL
    A2RSH6
    Related
    ENSMUSP00000147412.2, ENSMUST00000210748.2
    Conserved Domains (3) summary
    smart00091
    Location:141 → 198
    PAS; PAS domain
    pfam08447
    Location:316 → 387
    PAS_3; PAS fold
    cd19731
    Location:43 → 116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97459.1 GenPept UniProtKB/Swiss-Prot:P97459

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