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Nup50 nucleoporin 50 [ Mus musculus (house mouse) ]

Gene ID: 18141, updated on 28-Oct-2024

Summary

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Official Symbol
Nup50provided by MGI
Official Full Name
nucleoporin 50provided by MGI
Primary source
MGI:MGI:1351502
See related
Ensembl:ENSMUSG00000016619 AllianceGenome:MGI:1351502
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npap60; 1700030K07Rik
Summary
Acts upstream of or within neural tube formation. Part of nuclear pore. Is expressed in several structures, including nervous system and retina. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.0), placenta adult (RPKM 9.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nup50 in Genome Data Viewer
Location:
15 E2; 15 40.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84800100..84827164)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84923428..84942963)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46528 Neighboring gene RIKEN cDNA 4930513L16 gene Neighboring gene predicted gene 29666 Neighboring gene STARR-positive B cell enhancer ABC_E8603 Neighboring gene RIKEN cDNA 5031439G07 gene Neighboring gene microRNA 1249 Neighboring gene predicted gene, 39558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. Doufexis M, et al. FASEB J, 2007 Dec. PMID 17625072, Free PMC Article
  2. Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. Matsuura Y, et al. EMBO J, 2005 Nov 2. PMID 16222336, Free PMC Article
  3. Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. Müller D, et al. EMBO J, 2000 May 15. PMID 10811608, Free PMC Article
  4. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Buchwalter AL, et al. Mol Biol Cell, 2014 Aug 15. PMID 24943837, Free PMC Article
  5. cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Fan F, et al. Genomics, 1997 Mar 15. PMID 9073512

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that nucleoporin 50 plays an essential role in the survival of primordial germ cells during embryonic development
    Title: NUP50 is necessary for the survival of primordial germ cells in mouse embryos.
  2. Results suggest a transport-independent role for Nup50 in chromatin biology that occurs away from the NPC.
    Title: Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.
  3. Interacts with the melanocortin 2 receptor, participating in its translocation to the nucleus.
    Title: Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus.
  4. findings show that the Nup50 N-terminal domain actively displaces NLSs from importin-alpha, which would be more consistent with Nup50 functioning to coordinate import complex disassembly and importin recycling
    Title: Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
nuclear pore complex protein Nup50
Names
50 kDa nucleoporin
nuclear pore associated protein 60 kDa
nucleoporin Nup50
nucleoprotein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016714.2 → NP_057923.2  nuclear pore complex protein Nup50

    See identical proteins and their annotated locations for NP_057923.2

    Status: PROVISIONAL

    Source sequence(s)
    BC059239
    Consensus CDS
    CCDS27714.1
    UniProtKB/Swiss-Prot
    Q3TG43, Q3TN17, Q6P1F4, Q6PAL4, Q8C2Y6, Q9CU02, Q9JIH2, Q9JK85
    Related
    ENSMUSP00000131457.3, ENSMUST00000165443.4
    Conserved Domains (2) summary
    cd13170
    Location:348 → 464
    RanBD_NUP50; Nucleoporin 50 Ran-binding domain
    pfam08911
    Location:3 → 64
    NUP50; NUP50 (Nucleoporin 50 kDa)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    84800100..84827164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159225.1 → XP_036015118.1  nuclear pore complex protein Nup50 isoform X1

    Conserved Domains (2) summary
    cd13170
    Location:389 → 505
    RanBD_NUP50; Nucleoporin 50 Ran-binding domain
    pfam08911
    Location:3 → 105
    NUP50; NUP50 (Nucleoporin 50 kDa)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIH2.3 GenPept UniProtKB/Swiss-Prot:Q9JIH2

Gene LinkOut

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