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Nnat neuronatin [ Mus musculus (house mouse) ]

Gene ID: 18111, updated on 28-Oct-2024

Summary

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Official Symbol
Nnatprovided by MGI
Official Full Name
neuronatinprovided by MGI
Primary source
MGI:MGI:104716
See related
Ensembl:ENSMUSG00000067786 AllianceGenome:MGI:104716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Peg5; 5730414I02Rik
Summary
Acts upstream of or within positive regulation of insulin secretion and response to glucose. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human NNAT (neuronatin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 921.6), CNS E14 (RPKM 733.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Nnat in Genome Data Viewer
Location:
2 78.4 cM; 2 H1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157401936..157404445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157560078..157562525)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rous sarcoma oncogene Neighboring gene VISTA enhancer mm1673 Neighboring gene predicted gene 14279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:157392020-157392207 Neighboring gene bladder cancer associated protein Neighboring gene STARR-seq mESC enhancer starr_06215 Neighboring gene pluripotency associated transcript 27 Neighboring gene STARR-seq mESC enhancer starr_06217 Neighboring gene predicted gene, 34293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells. Joe MK, et al. Cell Signal, 2008 May. PMID 18289831
  2. Neuronatin Is Associated with an Anti-Inflammatory Role in the White Adipose Tissue. Ka HI, et al. J Microbiol Biotechnol, 2017 Jun 28. PMID 28335587
  3. Temporal and spatial expression pattern of Nnat during mouse eye development. Sel S, et al. Gene Expr Patterns, 2017 Jan. PMID 28038958
  4. Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice. Scott WR, et al. PLoS One, 2013. PMID 23527188, Free PMC Article
  5. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Millership SJ, et al. Mol Metab, 2018 Dec. PMID 30279096, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
    Title: DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
  2. Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
    Title: Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
  3. Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
    Title: Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
  4. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
    Title: Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
  5. Nnat deletion was associated with postnatal growth restriction and adult obesity.
    Title: Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice.
  6. investigation of the function of Nnat in the adipose tissue; results indicate that NNAT plays an anti-inflammatory role in the adipose tissue
    Title: Neuronatin Is Associated with an Anti-Inflammatory Role in the White Adipose Tissue.
  7. The expression pattern suggests that Nnat may play an important role during eye development and in the maintenance of mature eye.
    Title: Temporal and spatial expression pattern of Nnat during mouse eye development.
  8. Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction.
    Title: Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.
  9. Neuronatin appears to be a novel regulator of browning and metabolic substrate disposal in white adipocytes.
    Title: Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal.
  10. the Neuronatin locus employs the most basic mechanism for establishing allele-specific gene expression
    Title: An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291128.1 → NP_001278057.1  neuronatin isoform c

    See identical proteins and their annotated locations for NP_001278057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167, DN176829
    Consensus CDS
    CCDS71174.1
    UniProtKB/TrEMBL
    G3X9K1
    Related
    ENSMUSP00000085836.6, ENSMUST00000088484.6

  2. NM_001291129.1 → NP_001278058.1  neuronatin isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon but contains a different in-frame exon in the central coding region, compared to variant 3. The encoded isoform (d) is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167, DV062509
    Consensus CDS
    CCDS71175.1
    UniProtKB/TrEMBL
    G3UWR7
    Related
    ENSMUSP00000133397.2, ENSMUST00000173595.2

  3. NM_001291130.1 → NP_001278059.1  neuronatin isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167
    Consensus CDS
    CCDS79857.1
    UniProtKB/TrEMBL
    G3UWR4
    Related
    ENSMUSP00000133394.2, ENSMUST00000173839.2

  4. NM_010923.3 → NP_035053.1  neuronatin isoform alpha

    See identical proteins and their annotated locations for NP_035053.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (alpha, also known as Neuronatin-3) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167
    Consensus CDS
    CCDS38306.1
    UniProtKB/Swiss-Prot
    Q548Q0, Q61979, Q61980, Q61981
    Related
    ENSMUSP00000105152.2, ENSMUST00000109526.2

  5. NM_180960.3 → NP_851291.1  neuronatin isoform beta

    See identical proteins and their annotated locations for NP_851291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (beta, also known as Neuronatin-2) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, AU079843, BQ030646, BU705167
    Consensus CDS
    CCDS38307.1
    UniProtKB/TrEMBL
    Q548P9
    Related
    ENSMUSP00000129821.2, ENSMUST00000153739.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157401936..157404445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159369.1 → XP_036015262.1  neuronatin isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61979.2 GenPept UniProtKB/Swiss-Prot:Q61979

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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