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Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 18105, updated on 6-Jun-2024

Summary

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Official Symbol
Nqo2provided by MGI
Official Full Name
N-ribosyldihydronicotinamide quinone reductase 2provided by MGI
Primary source
MGI:MGI:104513
See related
Ensembl:ENSMUSG00000046949 AllianceGenome:MGI:104513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ox2; NMO2; Nmor2
Summary
Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in adenohypophysis. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 9.5), placenta adult (RPKM 5.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Nqo2 in Genome Data Viewer
Location:
13 A3.3; 13 14.01 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34148642..34172448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33964655..33988465)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6c Neighboring gene STARR-seq mESC enhancer starr_34132 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene STARR-positive B cell enhancer ABC_E2403 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene biphenyl hydrolase like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Celli CM, et al. Biochem Pharmacol, 2006 Jul 28. PMID 16765324
  2. Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3. Mailliet F, et al. FEBS Lett, 2004 Dec 3. PMID 15581627
  3. Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. Iskander K, et al. Cancer Res, 2004 Sep 1. PMID 15342368
  4. Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. Cassagnes LE, et al. Free Radic Biol Med, 2018 May 20. PMID 29526807
  5. NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease. Xu J, et al. J Biol Chem, 2013 Nov 29. PMID 24142791, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation.
    Title: Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation.
  2. these data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to reactive oxygen species-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals
    Title: Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.
  3. NQO2 stabilization of C/EBPalpha was independent of NQO1, even though both interacted with the same C/EBPa domain.
    Title: NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease.
  4. Melatonin, acting at least partially via MT2 receptors, can regulate the redox status of quinone reductase II inhibited preadipocytes.
    Title: Role of melatonin receptor MT(2) and quinone reductase II in the regulation of the redox status of 3T3-L1 preadipocytes in vitro.
  5. These data establish dihydronicotinamide riboside:quinone reductase 2 (NQO2) as part of the MT3 binding site.
    Title: Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3.
  6. role for NQO2 in protection against myelogenous hyperplasia and in metabolic activation of menadione, leading to hepatic toxicity
    Title: Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.
  7. NQO1 and NQO2 are endogenous factors in the regulation of immune response and autoimmunity
    Title: NQO1 and NQO2 regulation of humoral immunity and autoimmunity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
  
enables dihydronicotinamide riboside quinone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables melatonin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables resveratrol binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in quinone catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosyldihydronicotinamide dehydrogenase [quinone]
Names
NAD(P)H dehydrogenase, quinone 2
NAD(P)H menadione oxidoreductase 2, dioxin inducible
NRH dehydrogenase [quinone] 2
NRH: quinone oxidoreductase
NRH:quinone oxidoreductase 2
QR2
quinone reductase 2
ribosyldihydronicotinamide dehydrogenase
NP_001156711.1
NP_001156713.1
NP_001156714.1
NP_001413070.1
NP_001413071.1
NP_001413086.1
NP_001413090.1
NP_001413091.1
NP_001413092.1
NP_001413093.1
NP_001413095.1
NP_001413096.1
NP_001413102.1
NP_001413103.1
NP_001413104.1
NP_001413105.1
NP_001413107.1
NP_001413109.1
NP_064678.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163239.1 → NP_001156711.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

    See identical proteins and their annotated locations for NP_001156711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC161461, AK008465
    Consensus CDS
    CCDS88437.1
    UniProtKB/TrEMBL
    A0A1Y7VL95
    Related
    ENSMUSP00000152068.2, ENSMUST00000220844.2
    Conserved Domains (1) summary
    pfam02525
    Location:18 → 168
    Flavodoxin_2; Flavodoxin-like fold

  2. NM_001163241.2 → NP_001156713.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_001156713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC161461
    Consensus CDS
    CCDS26442.1
    UniProtKB/Swiss-Prot
    Q9JI75
    UniProtKB/TrEMBL
    Q9CVI1
    Related
    ENSMUSP00000053809.8, ENSMUST00000058978.9
    Conserved Domains (1) summary
    COG2249
    Location:4 → 215
    MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

  3. NM_001163242.2 → NP_001156714.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_001156714.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC161461
    Consensus CDS
    CCDS26442.1
    UniProtKB/Swiss-Prot
    Q9JI75
    UniProtKB/TrEMBL
    Q9CVI1
    Related
    ENSMUSP00000152294.2, ENSMUST00000222740.2
    Conserved Domains (1) summary
    COG2249
    Location:4 → 215
    MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

  4. NM_001426141.1 → NP_001413070.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/Swiss-Prot
    Q9JI75
    UniProtKB/TrEMBL
    Q9CVI1
    Related
    ENSMUSP00000152598.2, ENSMUST00000223479.2

  5. NM_001426142.1 → NP_001413071.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/Swiss-Prot
    Q9JI75
    UniProtKB/TrEMBL
    Q9CVI1

  6. NM_001426157.1 → NP_001413086.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/TrEMBL
    Q9CVI1

  7. NM_001426161.1 → NP_001413090.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/TrEMBL
    Q9CVI1

  8. NM_001426162.1 → NP_001413091.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/TrEMBL
    Q9CVI1

  9. NM_001426163.1 → NP_001413092.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161461

  10. NM_001426164.1 → NP_001413093.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161461

  11. NM_001426166.1 → NP_001413095.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC161461

  12. NM_001426167.1 → NP_001413096.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC161461

  13. NM_001426173.1 → NP_001413102.1  ribosyldihydronicotinamide dehydrogenase [quinone] isofom 7

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/TrEMBL
    A0A1Y7VL95

  14. NM_001426174.1 → NP_001413103.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC161461
    UniProtKB/TrEMBL
    A0A1Y7VL95

  15. NM_001426175.1 → NP_001413104.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC161461

  16. NM_001426176.1 → NP_001413105.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC161461

  17. NM_001426178.1 → NP_001413107.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC161461

  18. NM_001426180.1 → NP_001413109.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC161461

  19. NM_020282.4 → NP_064678.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_064678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC161461
    Consensus CDS
    CCDS26442.1
    UniProtKB/Swiss-Prot
    Q9JI75
    UniProtKB/TrEMBL
    Q9CVI1
    Related
    ENSMUSP00000021843.6, ENSMUST00000021843.13
    Conserved Domains (1) summary
    COG2249
    Location:4 → 215
    MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34148642..34172448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI75.3 GenPept UniProtKB/Swiss-Prot:Q9JI75

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