DPYSL3 dihydropyrimidinase like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DPYSL3provided by HGNC
Official Full Name: dihydropyrimidinase like 3provided by HGNC
Primary source: HGNC:HGNC:3015
See related: Ensembl:ENSG00000113657 MIM:601168; AllianceGenome:HGNC:3015
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
Summary: Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including cell body; growth cone; and lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in synapse. Predicted to colocalize with exocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in brain (RPKM 51.8), prostate (RPKM 49.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (147390808..147510068, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (147926586..148045847, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (146770371..146889631, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein predicts poor prognosis in urothelial carcinoma.
Title: Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein predicts poor prognosis in urothelial carcinoma.
Collapsin response mediator protein 4 enhances the radiosensitivity of colon cancer cells through calciummediated cell signaling.
Title: Collapsin response mediator protein 4 enhances the radiosensitivity of colon cancer cells through calcium‑mediated cell signaling.
Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer.
Title: Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer.
Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.
Title: Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.
Data found a damaging de novo missense CRMP4 mutation in a male autism spectrum disorders (ASD). Accumulating evidence suggests that a disturbance in the regulatory function of CRMP4 in forming neuronal networks is an important aspect underlying some characteristics of ASD, including sexual differences. These findings provide CRMP4 as a novel candidate gene contributing to ASD.
Title: Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
CRMP4 methylation levels >/=15% were significantly associated with a poor prognosis and their combination with CAPRA-S score accurately predicted tumor progression and metastasis
Title: Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients.
DPYSL3 expression identifies claudin-low (CLOW) tumors that will be sensitive to approaches that promote vimentin phosphorylation during mitosis and inhibitors of PAK signaling during migration and EMT.
Title: DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
Data indicate that CRMP4a and CRMP4b isoforms have opposite effects on cell proliferation, migration, and invasion in gastric cancer. CRMP4a expression was reduced in gastric carcinoma tissues and cell lines and seems to act as a tumor suppressor in gastric carcinoma. CRMP4b expression was higher in tumor tissue and cell lines.
Title: Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer.
DPYSL3 expression levels inversely correlated with those of VEGF and FAK. Down-regulation of DPYSL3 expression in HCC tissues may serve as a predictive biomarker for HCC after curative resection.
Title: Dihydropyrimidinase-like 3 is a putative hepatocellular carcinoma tumor suppressor.
Expression status of DPYSL3 in gastric cancer tissues may represent a promising biomarker for the malignant behavior of GC.
Title: Dihydropyrimidinase-like 3 facilitates malignant behavior of gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

1558 (e-PCR)
- UniSTS:49316

WI-14610 (e-PCR)
- UniSTS:22448

DPYSL3_8315 (e-PCR)
- UniSTS:467660

D5S563E (e-PCR)
- UniSTS:473048

RH66349 (e-PCR)
- UniSTS:85210

D5S564E (e-PCR)
- UniSTS:473057

WI-19514 (e-PCR)
- UniSTS:77799

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables filamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin crosslink formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to axon injury	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
colocalizes_with exocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of filamentous actin	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 3

Names: collapsin response mediator protein 4 long; testicular secretory protein Li 7; unc-33-like phosphoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197294.2 → NP_001184223.1 dihydropyrimidinase-related protein 3 isoform 1

See identical proteins and their annotated locations for NP_001184223.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC011373, BC077077, CA424493, D78014

Consensus CDS

CCDS56387.1

UniProtKB/TrEMBL

A0A140VK07, Q6DEN2

Related

ENSP00000343690.5, ENST00000343218.10

Conserved Domains (2) summary

TIGR02033
Location:131 → 585

D-hydantoinase

cl14632
Location:574 → 679

VOC; vicinal oxygen chelate (VOC) family
NM_001387.3 → NP_001378.1 dihydropyrimidinase-related protein 3 isoform 2

See identical proteins and their annotated locations for NP_001378.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform (1).

Source sequence(s)

AI570709, BC039006, CA424493, D78014

Consensus CDS

CCDS43381.1

UniProtKB/Swiss-Prot

B3SXQ8, Q14195, Q93012

UniProtKB/TrEMBL

Q8IXW6

Related

ENSP00000381526.3, ENST00000398514.7

Conserved Domains (1) summary

TIGR02033
Location:17 → 471

D-hydantoinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

147390808..147510068 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537574.3 → XP_011535876.1 dihydropyrimidinase-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_011535876.1

UniProtKB/TrEMBL

Q8IXW6

Conserved Domains (2) summary

TIGR02033
Location:13 → 467

D-hydantoinase

cl14632
Location:456 → 561

VOC; vicinal oxygen chelate (VOC) family