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pfut-1 GDP-fucose protein O-fucosyltransferase 1 [ Caenorhabditis elegans ]

Gene ID: 180607, updated on 2-Nov-2024

Summary

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Official Symbol
pfut-1
Official Full Name
GDP-fucose protein O-fucosyltransferase 1
Primary source
WormBase:WBGene00015793
Locus tag
CELE_C15C7.7
See related
AllianceGenome:WB:WBGene00015793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peptide-O-fucosyltransferase activity. Involved in protein O-linked fucosylation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pfut-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (3165826..3167579)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GRIP domain-containing protein Neighboring gene Putative syntaxin 6 Neighboring gene ncRNA Neighboring gene Glycoprotein Neighboring gene Kinesin motor domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Asparagine Tautomerization in Glycosyltransferase Catalysis. The Molecular Mechanism of Protein O-Fucosyltransferase 1. Piniello B, et al. ACS Catal, 2021 Aug 6. PMID 34868727, Free PMC Article
  2. Structural insights into the mechanism of protein O-fucosylation. Lira-Navarrete E, et al. PLoS One, 2011. PMID 21966509, Free PMC Article
  3. A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2. Valero-González J, et al. Nat Chem Biol, 2016 Apr. PMID 26854667, Free PMC Article
  4. Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats. Kozma K, et al. J Biol Chem, 2006 Dec 1. PMID 17032646
  5. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. Wang Y, et al. J Biol Chem, 2001 Oct 26. PMID 11524432

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-O-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-O-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked fucosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
GDP-fucose protein O-fucosyltransferase 1
NP_741744.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3165826..3167579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171649.8 → NP_741744.2  GDP-fucose protein O-fucosyltransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741744.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18014
    UniProtKB/TrEMBL
    Q00P41
    Conserved Domains (2) summary
    cd11302
    Location:27 → 381
    O-FucT-1; GDP-fucose protein O-fucosyltransferase 1
    pfam10250
    Location:37 → 374
    O-FucT; GDP-fucose protein O-fucosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18014.5

Gene LinkOut

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