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nlf-1 NCA Localization Factor [ Caenorhabditis elegans ]

Gene ID: 180454, updated on 2-Nov-2024

Summary

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Official Symbol
nlf-1
Official Full Name
NCA Localization Factor
Primary source
WormBase:WBGene00018854
Locus tag
CELE_F55A4.2
See related
AllianceGenome:WB:WBGene00018854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in protein localization to axon and protein-containing complex assembly. Located in endoplasmic reticulum. Is expressed in nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nlf-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (1012715..1017567, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Action potentials drive body wall muscle contractions in Caenorhabditis elegans. Gao S, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21248227, Free PMC Article
  2. The NCA-1 and NCA-2 Ion Channels Function Downstream of G(q) and Rho To Regulate Locomotion in Caenorhabditis elegans. Topalidou I, et al. Genetics, 2017 May. PMID 28325749, Free PMC Article
  3. NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion. Xie L, et al. Neuron, 2013 Mar 20. PMID 23522043
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein localization to axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NCA Localization Factor
NP_001350981.1
  • Product from WormBase gene class nlf;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1012715..1017567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001364050.5 → NP_001350981.1  NCA Localization Factor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M4Q8W4
Nucleotide Protein
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