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swsn-1 SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180324, updated on 2-Nov-2024

Summary

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Official Symbol
swsn-1
Official Full Name
SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein
Primary source
WormBase:WBGene00004203
Locus tag
CELE_Y113G7B.23
See related
AllianceGenome:WB:WBGene00004203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of vulval development; and positive regulation of growth rate. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex. Is expressed widely. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See swsn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (20239182..20249488, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Pept_C1 domain-containing protein Neighboring gene DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5 C-terminal domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 17 Neighboring gene Protein arginine N-methyltransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of chromatin states and gene expression during HSN neuronal maturation is mediated by EOR-1/PLZF, MAU-2/cohesin loader, and SWI/SNF complex. Shinkai Y, et al. Sci Rep, 2018 May 21. PMID 29786685, Free PMC Article
  2. SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol. Mathies LD, et al. BMC Genomics, 2020 Sep 21. PMID 32957927, Free PMC Article
  3. Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function. Lampersberger L, et al. Proc Natl Acad Sci U S A, 2023 Jan 31. PMID 36689659, Free PMC Article
  4. Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan. Bansal A, et al. Longev Healthspan, 2014. PMID 24834345, Free PMC Article
  5. Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. Sawa H, et al. Mol Cell, 2000 Sep. PMID 11030341

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
    Title: SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein
NP_001256906.1
  • Confirmed by transcript evidence
NP_001256907.1
  • Confirmed by transcript evidence
NP_001256908.1
  • Confirmed by transcript evidence
NP_001360451.1
  • Confirmed by transcript evidence
NP_001360453.1
  • Confirmed by transcript evidence
NP_001368722.1
  • Confirmed by transcript evidence
NP_001380243.1
  • Confirmed by transcript evidence
NP_001380244.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20239182..20249488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269977.5 → NP_001256906.1  SWI/SNF complex subunit SMARCC2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF87
    Conserved Domains (2) summary
    COG5259
    Location:33 → 509
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam16498
    Location:354 → 415
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  2. NM_001392706.1 → NP_001380243.1  SANT domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6P9B9
    Conserved Domains (3) summary
    COG5259
    Location:1 → 239
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam16495
    Location:189 → 264
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16498
    Location:84 → 145
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  3. NM_001269978.4 → NP_001256907.1  SWI/SNF complex subunit SMARCC2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8ESF3
    Conserved Domains (2) summary
    COG5259
    Location:33 → 509
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam16498
    Location:354 → 415
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  4. NM_001269979.3 → NP_001256908.1  SANT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256908.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8ESF4
    Conserved Domains (2) summary
    COG5259
    Location:2 → 405
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam16498
    Location:250 → 311
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  5. NM_001380878.1 → NP_001368722.1  SANT domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6NNV9
    Conserved Domains (2) summary
    COG5259
    Location:2 → 405
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam16498
    Location:250 → 311
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  6. NM_001373203.2 → NP_001360451.1  SANT domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6NPD2
    Conserved Domains (3) summary
    COG5259
    Location:1 → 239
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam16495
    Location:189 → 264
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16498
    Location:84 → 145
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  7. NM_001392707.1 → NP_001380244.1  SWIRM-assoc_1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6MYA1
    Conserved Domains (2) summary
    pfam16495
    Location:116 → 191
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16498
    Location:11 → 72
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  8. NM_001373205.2 → NP_001360453.1  SWIRM-assoc_1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6N6K6
    Conserved Domains (2) summary
    pfam16495
    Location:116 → 191
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16498
    Location:11 → 72
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal
Nucleotide Protein
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