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gly-4 Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase [ Caenorhabditis elegans ]

Gene ID: 180302, updated on 2-Nov-2024

Summary

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Official Symbol
gly-4
Official Full Name
Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase
Primary source
WormBase:WBGene00001629
Locus tag
CELE_Y116F11B.12
See related
AllianceGenome:WB:WBGene00001629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to several human genes including GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gly-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (19881374..19895350, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene SCP domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene FDX-ACB domain-containing protein;phenylalanine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Hagen FK, et al. J Biol Chem, 1998 Apr 3. PMID 9525933
  2. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Wang H, et al. Mol Biol Cell, 2005 Sep. PMID 15987734, Free PMC Article
  3. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Schwientek T, et al. J Biol Chem, 2002 Jun 21. PMID 11925450
  4. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
  5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase
NP_001024216.1
  • Confirmed by transcript evidence
NP_001256888.1
  • Confirmed by transcript evidence
NP_001379271.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    19881374..19895350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029045.6 → NP_001024216.1  Polypeptide N-acetylgalactosaminyltransferase 4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61390, Q8I136
    Conserved Domains (3) summary
    cd02510
    Location:154 → 449
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:469 → 582
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:469 → 580
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001392704.1 → NP_001379271.1  Polypeptide N-acetylgalactosaminyltransferase 4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd02510
    Location:154 → 449
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

  3. NM_001269959.4 → NP_001256888.1  polypeptide N-acetylgalactosaminyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6S3M5
    Conserved Domains (1) summary
    cd02510
    Location:154 → 449
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I136.2

Gene LinkOut

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