H12D21.10 EGF domain-specific O-linked N-acetylglucosamine transferase;Heparan N-sulfatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: H12D21.10
Official Full Name: EGF domain-specific O-linked N-acetylglucosamine transferase;Heparan N-sulfatase
Primary source: WormBase:WBGene00010386
Locus tag: CELE_H12D21.10
See related: AllianceGenome:WB:WBGene00010386
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-GlcNAcylation via threonine. Predicted to be active in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See H12D21.10 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 13

Sequence:: Chromosome: V; NC_003283.11 (14899804..14911929)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

H12D21.8 (e-PCR)
- UniSTS:306950

H20H17.1 (e-PCR)
- UniSTS:312395

C10B5.2 (e-PCR)
- UniSTS:315473

H12D21.9 (e-PCR)
- UniSTS:313211

STS5-222 (e-PCR)
- UniSTS:242386

H12D21.10 (e-PCR)
- UniSTS:316887

H12D21.7 (e-PCR)
- UniSTS:316889

F25G6.1 (e-PCR)
- UniSTS:312292

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein O-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein O-GlcNAcylation via threonine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EGF domain-specific O-linked N-acetylglucosamine transferase;Heparan N-sulfatase

NP_001129900.1

Confirmed by transcript evidence

NP_506677.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14899804..14911929

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074276.8 → NP_506677.3 EGF domain-specific O-linked N-acetylglucosamine transferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506677.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9XTX0

Conserved Domains (1) summary

pfam04577
Location:224 → 447

DUF563; Protein of unknown function (DUF563)
NM_001136428.4 → NP_001129900.1 Heparan N-sulfatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129900.1

Status: REVIEWED

UniProtKB/TrEMBL

B5BM48

Conserved Domains (1) summary

cl15705
Location:1 → 44

DUF563; Protein of unknown function (DUF563)