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Ncl nucleolin [ Mus musculus (house mouse) ]

Gene ID: 17975, updated on 2-Nov-2024

Summary

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Official Symbol
Nclprovided by MGI
Official Full Name
nucleolinprovided by MGI
Primary source
MGI:MGI:97286
See related
Ensembl:ENSMUSG00000026234 AllianceGenome:MGI:97286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C23; Nucl; D0Nds28; D1Nds28; B530004O11Rik
Summary
Enables PH domain binding activity; RNA binding activity; and insulin receptor substrate binding activity. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Located in nucleolus and nucleoplasm. Is active in cornified envelope. Is expressed in several structures, including 1st branchial arch mandibular component; blastocyst; central nervous system; early embryo; and tooth. Orthologous to human NCL (nucleolin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 52.4), liver E14 (RPKM 41.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Ncl in Genome Data Viewer
Location:
1 C5; 1 43.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86272441..86287177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86344719..86359455, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated B3gnt7 cis-regulatory element Neighboring gene predicted gene 28626 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Neighboring gene predicted gene 5258 Neighboring gene STARR-seq mESC enhancer starr_01572 Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene microRNA 3535 Neighboring gene RIKEN cDNA C130036L24 gene Neighboring gene STARR-positive B cell enhancer ABC_E406 Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene neuromedin U receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional implication of nucleolin in the mouse first molar development. Xie M, et al. J Biol Chem, 2007 Aug 10. PMID 17562718
  2. Nucleolin is a receptor for maleylated-bovine serum albumin on macrophages. Miki Y, et al. Biol Pharm Bull, 2015. PMID 25744467
  3. Macrophage recognition of toxic advanced glycosylation end products through the macrophage surface-receptor nucleolin. Miki Y, et al. Biol Pharm Bull, 2014. PMID 24818254
  4. Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages. Miki Y, et al. Biol Pharm Bull, 2015. PMID 26328500
  5. Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway. Yang A, et al. J Biol Chem, 2011 Dec 16. PMID 22013067, Free PMC Article

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA Snhg15 promotes preosteoblast proliferation by interacting with and stabilizing nucleolin.
    Title: Long non-coding RNA Snhg15 promotes preosteoblast proliferation by interacting with and stabilizing nucleolin.
  2. Nucleolin myocardial-specific knockout exacerbates glucose metabolism disorder in endotoxemia-induced myocardial injury.
    Title: Nucleolin myocardial-specific knockout exacerbates glucose metabolism disorder in endotoxemia-induced myocardial injury.
  3. RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.
    Title: RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.
  4. NUCLEOLIN PROTECTS CARDIOMYOCYTES BY UPREGULATING PGC-1alpha AND PROMOTING MITOCHONDRIAL BIOGENESIS IN LPS-INDUCED MYOCARDIAL INJURY.
    Title: NUCLEOLIN PROTECTS CARDIOMYOCYTES BY UPREGULATING PGC-1α AND PROMOTING MITOCHONDRIAL BIOGENESIS IN LPS-INDUCED MYOCARDIAL INJURY.
  5. The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization.
    Title: The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization.
  6. LncRNA H19 is involved in myocardial ischemic preconditioning via increasing the stability of nucleolin protein.
    Title: LncRNA H19 is involved in myocardial ischemic preconditioning via increasing the stability of nucleolin protein.
  7. Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin.
    Title: Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin.
  8. Growth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin.
    Title: Growth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin.
  9. Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation.
    Title: Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation.
  10. TLR4 and nucleolin influence cell injury, apoptosis and inflammatory factor expression in respiratory syncytial virus-infected N2a neuronal cells.
    Title: TLR4 and nucleolin influence cell injury, apoptosis and inflammatory factor expression in respiratory syncytial virus-infected N2a neuronal cells.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA topoisomerase binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase binding ISO
Inferred from Sequence Orthology
more info
  
enables ErbB-4 class receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables PH domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA primary transcript binding ISO
Inferred from Sequence Orthology
more info
  
enables selenocysteine insertion sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomeric DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in dense fibrillar component ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010880.3 → NP_035010.3  nucleolin

    See identical proteins and their annotated locations for NP_035010.3

    Status: VALIDATED

    Source sequence(s)
    AC102609, AK144894, CJ084318
    Consensus CDS
    CCDS35646.1
    UniProtKB/Swiss-Prot
    P09405, Q548M9, Q61991, Q8BQD8, Q99K50
    UniProtKB/TrEMBL
    Q3TGR3, Q3TT41
    Related
    ENSMUSP00000027438.7, ENSMUST00000027438.8
    Conserved Domains (4) summary
    cd12403
    Location:309 → 383
    RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
    cd12404
    Location:392 → 467
    RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
    cd12405
    Location:486 → 558
    RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
    cd12406
    Location:569 → 646
    RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    86272441..86287177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529238.4 → XP_006529301.1  nucleolin isoform X1

    UniProtKB/TrEMBL
    Q3TGR3, Q3TT41
    Conserved Domains (5) summary
    PRK10905
    Location:34 → 124
    PRK10905; cell division protein DamX; Validated
    cd12403
    Location:293 → 367
    RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
    cd12404
    Location:376 → 451
    RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
    cd12405
    Location:470 → 542
    RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
    cd12406
    Location:553 → 630
    RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09405.2 GenPept UniProtKB/Swiss-Prot:P09405

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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