gly-20 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gly-20
Official Full Name: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Primary source: WormBase:WBGene00001645
Locus tag: CELE_C03E10.4
See related: AllianceGenome:WB:WBGene00001645
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi stack and membrane. Predicted to be active in Golgi membrane. Used to study carbohydrate metabolic disorder. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gly-20 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (11282572..11286039)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C03E10.4 (e-PCR)
- UniSTS:321178

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

NP_505864.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11282572..11286039

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073463.9 → NP_505864.1 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505864.1

Status: REVIEWED

UniProtKB/TrEMBL

O17560, Q9NGK7

Conserved Domains (1) summary

pfam05060
Location:101 → 447

MGAT2; N-acetylglucosaminyltransferase II (MGAT2)