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Myt1 myelin transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 17932, updated on 2-Nov-2024

Summary

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Official Symbol
Myt1provided by MGI
Official Full Name
myelin transcription factor 1provided by MGI
Primary source
MGI:MGI:1100535
See related
Ensembl:ENSMUSG00000010505 AllianceGenome:MGI:1100535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nzf2; Nzf2a; Nzf2b; Nztf2
Summary
This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression
Biased expression in CNS E14 (RPKM 7.7), whole brain E14.5 (RPKM 7.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Myt1 in Genome Data Viewer
Location:
2 H4; 2 103.77 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181405099..181469579)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181763332..181827775)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid receptor-like 1 Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06758 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181598872-181599172 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1. Gamsjaeger R, et al. J Biol Chem, 2008 Feb 22. PMID 18073212
  2. A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers. Gamsjaeger R, et al. J Biol Chem, 2013 Dec 6. PMID 24097990, Free PMC Article
  3. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. Vana AC, et al. Glia, 2007 May. PMID 17330875, Free PMC Article
  4. NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones. Matsushita F, et al. Mech Dev, 2002 Oct. PMID 12351189
  5. A tool for examining the role of the zinc finger myelin transcription factor 1 (Myt1) in neural development: Myt1 knock-in mice. Hudson LD, et al. Transgenic Res, 2011 Aug. PMID 21267777, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we show that Ascl1 induces the transcription factor MyT1 while promoting neuronal differentiation...It promotes neuronal differentiation by counteracting the inhibitory activity of Notch signaling at multiple levels, targeting the Notch1 receptor and many of its downstream targets
    Title: MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.
  2. NZF-1 was expressed later in post-mitotic neurons. NZF-2 was initially expressed in neuronal cells a little earlier than NZF-3. NZF-3 was initially expressed in neuronal cells, just after proliferation was complete.
    Title: Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development.
  3. MyT1 is a subunit of the neural cell type-specific LSD1 complex.
    Title: Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.
  4. used NMR spectroscopy, in combination with surface plasmon resonance and data-driven molecular docking, to delineate the mechanism of DNA binding for double zinc finger polypeptides derived from MyT1
    Title: A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.
  5. These results suggest a potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination.
    Title: Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS.
  6. Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.
    Title: Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.
  7. MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
    Title: Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.
  8. These findings suggest Myt1 is involved in proper endocrine differentiation and function.
    Title: Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
  9. in embryonic mouse nervous system, the expression of NZF-2b starts as early as at 9.5 days post-coitum (dpc) in newly differentiated neurons in the central nervous system (CNS) and the peripheral nervous system (PNS)
    Title: NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones.
  10. Expression of Myt1 inhibited the differentiation of progenitors into oligodendrocytes as assessed by morphology, immunostaining, and myelin gene expression. Progenitor differentiation was similarly inhibited by expression of Myt1.
    Title: Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0835

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within diaphragm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myelin transcription factor 1
Names
NZF-2
neural zinc finger factor 2
neural zinc finger transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171615.2 → NP_001165086.1  myelin transcription factor 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 3) that maintains the reading frame but is longer at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL845173
    Consensus CDS
    CCDS50856.1
    UniProtKB/TrEMBL
    B0R0C1
    Related
    ENSMUSP00000079900.5, ENSMUST00000081125.11
    Conserved Domains (3) summary
    pfam01530
    Location:887 → 913
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:604 → 835
    MYT1; Myelin transcription factor 1
    pfam14357
    Location:1045 → 1118
    DUF4404; Domain of unknown function (DUF4404)

  2. NM_001171616.2 → NP_001165087.1  myelin transcription factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001165087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AL845173
    Consensus CDS
    CCDS50857.1
    UniProtKB/Swiss-Prot
    Q8CFC2
    Related
    ENSMUSP00000104388.3, ENSMUST00000108757.9
    Conserved Domains (3) summary
    TIGR04523
    Location:957 → 1029
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:807 → 835
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:524 → 755
    MYT1; Myelin transcription factor 1

  3. NM_001420423.1 → NP_001407352.1  myelin transcription factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL845173

  4. NM_001420424.1 → NP_001407353.1  myelin transcription factor 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL845173

  5. NM_008665.5 → NP_032691.2  myelin transcription factor 1 isoform 1

    See identical proteins and their annotated locations for NP_032691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL845173
    Consensus CDS
    CCDS17223.1
    UniProtKB/Swiss-Prot
    B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
    Related
    ENSMUSP00000104387.2, ENSMUST00000108756.8
    Conserved Domains (3) summary
    TIGR04523
    Location:995 → 1067
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:845 → 873
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562 → 793
    MYT1; Myelin transcription factor 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181405099..181469579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159141.1 → XP_036015034.1  myelin transcription factor 1 isoform X6

    Conserved Domains (3) summary
    TIGR04523
    Location:999 → 1071
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:849 → 877
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:566 → 797
    MYT1; Myelin transcription factor 1

  2. XM_036159150.1 → XP_036015043.1  myelin transcription factor 1 isoform X8

    Conserved Domains (3) summary
    TIGR04523
    Location:978 → 1050
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:828 → 856
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:545 → 776
    MYT1; Myelin transcription factor 1

  3. XM_036159159.1 → XP_036015052.1  myelin transcription factor 1 isoform X10

    Conserved Domains (3) summary
    TIGR04523
    Location:907 → 979
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:757 → 785
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:474 → 705
    MYT1; Myelin transcription factor 1

  4. XM_036159155.1 → XP_036015048.1  myelin transcription factor 1 isoform X9

    Conserved Domains (3) summary
    TIGR04523
    Location:974 → 1046
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:824 → 852
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:541 → 772
    MYT1; Myelin transcription factor 1

  5. XM_006500581.5 → XP_006500644.2  myelin transcription factor 1 isoform X12

    Conserved Domains (2) summary
    pfam01530
    Location:845 → 873
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562 → 793
    MYT1; Myelin transcription factor 1

  6. XM_036159123.1 → XP_036015016.1  myelin transcription factor 1 isoform X3

    Conserved Domains (3) summary
    TIGR04523
    Location:972 → 1044
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:822 → 850
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562 → 793
    MYT1; Myelin transcription factor 1

  7. XM_036159133.1 → XP_036015026.1  myelin transcription factor 1 isoform X5

    Conserved Domains (3) summary
    TIGR04523
    Location:951 → 1023
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:801 → 829
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562 → 793
    MYT1; Myelin transcription factor 1

  8. XM_006500577.5 → XP_006500640.2  myelin transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006500640.2

    UniProtKB/Swiss-Prot
    B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
    Conserved Domains (3) summary
    TIGR04523
    Location:995 → 1067
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:845 → 873
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562 → 793
    MYT1; Myelin transcription factor 1

  9. XM_006500579.5 → XP_006500642.2  myelin transcription factor 1 isoform X4

    See identical proteins and their annotated locations for XP_006500642.2

    UniProtKB/Swiss-Prot
    Q8CFC2
    Conserved Domains (3) summary
    TIGR04523
    Location:957 → 1029
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:807 → 835
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:524 → 755
    MYT1; Myelin transcription factor 1

  10. XM_006500578.5 → XP_006500641.1  myelin transcription factor 1 isoform X2

    Conserved Domains (3) summary
    TIGR04523
    Location:1054 → 1126
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:904 → 932
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:621 → 852
    MYT1; Myelin transcription factor 1

  11. XM_036159160.1 → XP_036015053.1  myelin transcription factor 1 isoform X10

    Conserved Domains (3) summary
    TIGR04523
    Location:907 → 979
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:757 → 785
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:474 → 705
    MYT1; Myelin transcription factor 1

  12. XM_036159162.1 → XP_036015055.1  myelin transcription factor 1 isoform X11

    Conserved Domains (3) summary
    TIGR04523
    Location:884 → 956
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:734 → 762
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:474 → 705
    MYT1; Myelin transcription factor 1

RNA

  1. XR_375392.5 RNA Sequence

  2. XR_004938798.1 RNA Sequence

  3. XR_001781155.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171680.1: Suppressed sequence

    Description
    NM_001171680.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFC2.1 GenPept UniProtKB/Swiss-Prot:Q8CFC2

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