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unc-23 BAG domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179272, updated on 2-Nov-2024

Summary

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Official Symbol
unc-23
Official Full Name
BAG domain-containing protein
Primary source
WormBase:WBGene00006760
Locus tag
CELE_H14N18.1
See related
AllianceGenome:WB:WBGene00006760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Is expressed in several structures, including excretory canal; hypodermis; muscle cell; neurons; and pharynx. Orthologous to human BAG2 (BAG cochaperone 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-23 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (8936359..8939684)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF2726 domain-containing protein Neighboring gene ncRNA Neighboring gene Atrophin-1 multi-domain protein;DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the effects of turning bias on chemotaxis in C. elegans. Pierce-Shimomura JT, et al. J Exp Biol, 2005 Dec. PMID 16326954
  2. Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans. Martin CG, et al. Dev Cell, 2024 Jul 8. PMID 38670103,
  3. The C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity. Rahmani P, et al. Worm, 2015 Apr-Jun. PMID 26435886, Free PMC Article
  4. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Fukuzono T, et al. Genes Cells, 2016 Apr. PMID 26853528
  5. Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants. Ward S. Proc Natl Acad Sci U S A, 1973 Mar. PMID 4351805, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.
    Title: Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.
  2. Study investigated the role of UNC-23 and HSP-1 on LRK-1 function in C. elegans; results suggest that the UNC-23-HSP-1 chaperone complex regulates LRK-1 localization to the Golgi apparatus and consequently determines the polarized sorting of synaptic vesicle proteins to the axons.
    Title: Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.
  3. Data indicate that UNC-23 protein interacts with molecular chaperone Hsc70, whose uncoupling from DNJ-13 protein cures the muscular phenotype.
    Title: The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BAG domain-containing protein
NP_001380002.1
  • Confirmed by transcript evidence
NP_505307.1
  • Confirmed by transcript evidence
NP_872142.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8936359..8939684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072906.7 → NP_505307.1  BAG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505307.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61980
    Conserved Domains (2) summary
    smart00264
    Location:370 → 450
    BAG; BAG domains, present in regulator of Hsp70 proteins
    TIGR02168
    Location:275 → 452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001392570.1 → NP_001380002.1  BAG domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5TKA9
    Conserved Domains (2) summary
    smart00264
    Location:369 → 449
    BAG; BAG domains, present in regulator of Hsp70 proteins
    TIGR02168
    Location:274 → 451
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_182342.6 → NP_872142.1  BAG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872142.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86S24
    Conserved Domains (2) summary
    smart00264
    Location:311 → 391
    BAG; BAG domains, present in regulator of Hsp70 proteins
    TIGR02168
    Location:216 → 393
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein
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