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sul-2 Sulfatase N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179194, updated on 28-Oct-2024

Summary

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Official Symbol
sul-2
Official Full Name
Sulfatase N-terminal domain-containing protein
Primary source
WormBase:WBGene00006309
Locus tag
CELE_D1014.1
See related
AllianceGenome:WB:WBGene00006309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity. Is expressed in chemosensory neurons. Human ortholog(s) of this gene implicated in X-linked chondrodysplasia punctata 1; X-linked ichthyosis; chondrodysplasia punctata; metachromatic leukodystrophy; and mucopolysaccharidosis IVA. Orthologous to several human genes including STS (steroid sulfatase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See sul-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (8157746..8159872)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Serine/threonine specific protein phosphatases domain-containing protein Neighboring gene CHK kinase-like domain-containing protein Neighboring gene GTP-binding protein Rheb

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases. Pérez-Jiménez MM, et al. Nat Commun, 2021 Jan 4. PMID 33397961, Free PMC Article
  2. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356
  3. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases.
    Title: Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sulfatase N-terminal domain-containing protein
NP_505102.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8157746..8159872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072701.6 → NP_505102.1  Sulfatase N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18924
    Conserved Domains (1) summary
    cl23718
    Location:32 → 388
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein
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