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spn-4 RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179070, updated on 2-Nov-2024

Summary

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Official Symbol
spn-4
Official Full Name
RRM domain-containing protein
Primary source
WormBase:WBGene00004984
Locus tag
CELE_ZC404.8
See related
AllianceGenome:WB:WBGene00004984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Located in P granule. Is expressed in several structures, including AB; C; D; germ line; and oocyte. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spn-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (6783187..6784903, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene Spermatogenesis-defective protein 39 Neighboring gene ABC transporter permease Neighboring gene Mitogen-activated protein kinase kinase kinase kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Kuroyanagi H, et al. Nat Methods, 2006 Nov. PMID 17060915
  2. Gene Cascade Finder: A tool for identification of gene cascades and its application in Caenorhabditis elegans. Nomoto Y, et al. PLoS One, 2019. PMID 31504044, Free PMC Article
  3. Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells. Jadhav S, et al. Development, 2008 May. PMID 18417623, Free PMC Article
  4. The RNA binding protein MEX-3 retains asymmetric activity in the early Caenorhabditis elegans embryo in the absence of asymmetric protein localization. Huang NN, et al. Gene, 2015 Jan 10. PMID 25445286
  5. PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos. Wu JC, et al. Mol Biol Cell, 2007 Nov. PMID 17761536, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the balance between POS-1 and SPN-4 controls the translation of maternal glp-1 mRNA
    Title: Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RRM domain-containing protein
NP_504717.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6783187..6784903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072316.7 → NP_504717.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504717.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF02
    Conserved Domains (1) summary
    cl17169
    Location:51 → 126
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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