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lipl-4 Lipase lipl-4 [ Caenorhabditis elegans ]

Gene ID: 179046, updated on 2-Nov-2024

Summary

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Official Symbol
lipl-4
Official Full Name
Lipase lipl-4
Primary source
WormBase:WBGene00019376
Locus tag
CELE_K04A8.5
See related
AllianceGenome:WB:WBGene00019376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables triacylglycerol lipase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macroautophagy; and triglyceride catabolic process. Located in lysosome. Is expressed in intestine and seam cell. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lipl-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (6550171..6552186)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene Potassium channel domain-containing protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Saposin B-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases. Shemesh N, et al. Front Mol Neurosci, 2017. PMID 28503130, Free PMC Article
  2. Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans. Liu YJ, et al. Sci Rep, 2022 Mar 1. PMID 35233004, Free PMC Article
  3. Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. Ramachandran PV, et al. Dev Cell, 2019 Mar 11. PMID 30713071, Free PMC Article
  4. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Folick A, et al. Science, 2015 Jan 2. PMID 25554789, Free PMC Article
  5. Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans. Wu Z, et al. Molecules, 2022 Sep 20. PMID 36234692, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
    Title: Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
  2. Autophagy and lipase LIPL-4 modulate aging in germline-deficient C. elegans by maintaining lipid homeostasis to prolong life span.
    Title: Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
  3. germline stem cell arrest promotes lipolysis via induction of lipase; fat mobilization is promoted & life span prolonged; constitutive expression of this lipase in fat storage tissue generates lean, long-lived animals
    Title: Fat metabolism links germline stem cells and longevity in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lipase lipl-4
NP_001300136.1
  • Confirmed by transcript evidence
NP_504662.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6550171..6552186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072261.5 → NP_504662.1  Lipase lipl-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504662.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AUZ3, Q94252
    Conserved Domains (1) summary
    PLN02872
    Location:38 → 399
    PLN02872; triacylglycerol lipase

  2. NM_001313207.3 → NP_001300136.1  Lipase lipl-4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUZ3
    Conserved Domains (1) summary
    PLN02872
    Location:14 → 242
    PLN02872; triacylglycerol lipase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94252.1

Gene LinkOut

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