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W01A11.1 Epoxide hydrolase;Microsomal epoxide hydrolase [ Caenorhabditis elegans ]

Gene ID: 179036, updated on 2-Nov-2024

Summary

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Official Symbol
W01A11.1
Official Full Name
Epoxide hydrolase;Microsomal epoxide hydrolase
Primary source
WormBase:WBGene00020909
Locus tag
CELE_W01A11.1
See related
AllianceGenome:WB:WBGene00020909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cis-stilbene-oxide hydrolase activity. Predicted to be involved in catabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including anal sphincter muscle; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See W01A11.1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (6499224..6502428)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene Acyltransferase Neighboring gene molybdopterin molybdotransferase Neighboring gene DUF2382 domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-stilbene-oxide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ether hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in epoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Epoxide hydrolase;Microsomal epoxide hydrolase
NP_001300208.1
  • Confirmed by transcript evidence
NP_504650.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6499224..6502428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072249.9 → NP_504650.1  Epoxide hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504650.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23068
    Conserved Domains (3) summary
    COG0596
    Location:122 → 449
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam06441
    Location:51 → 153
    EHN; Epoxide hydrolase N terminus
    cl21494
    Location:126 → 232
    Abhydrolase; alpha/beta hydrolases

  2. NM_001313279.3 → NP_001300208.1  Microsomal epoxide hydrolase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVX4
    Conserved Domains (1) summary
    pfam00561
    Location:1 → 129
    Abhydrolase_1; alpha/beta hydrolase fold
Nucleotide Protein
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