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cmd-1 Calmodulin;EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178614, updated on 2-Nov-2024

Summary

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Official Symbol
cmd-1
Official Full Name
Calmodulin;EF-hand domain-containing protein
Primary source
WormBase:WBGene00000552
Locus tag
CELE_T21H3.3
See related
AllianceGenome:WB:WBGene00000552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and enzyme regulator activity. Involved in several processes, including apoptotic cell clearance; establishment of meiotic spindle orientation; and positive chemotaxis. Located in cell periphery; microtubule cytoskeleton; and nuclear membrane. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; long QT syndrome 15; and long QT syndrome 16. Orthologous to human CALM1 (calmodulin 1); CALM2 (calmodulin 2); and CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cmd-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (1156271..1158189)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of the single calmodulin gene in the nematode Caenorhabditis elegans by RNA interference and 4-D microscopy. Karabinos A, et al. Eur J Cell Biol, 2003 Nov. PMID 14703012
  2. Social feeding in Caenorhabditis elegans is modulated by antipsychotic drugs and calmodulin and may serve as a protophenotype for asociality. Dwyer DS, et al. Neuropharmacology, 2015 May. PMID 25576370
  3. Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans. Allman E, et al. J Biol Chem, 2013 Feb 22. PMID 23319594, Free PMC Article
  4. Neuronal calmodulin levels are controlled by CAMTA transcription factors. Vuong-Brender TT, et al. Elife, 2021 Sep 9. PMID 34499028, Free PMC Article
  5. A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function. Hudgins AD, et al. Neuron, 2024 Jul 3. PMID 38692279,

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASPM-1, together with calmodulin (CMD-1), promotes meiotic spindle organization and the accumulation of LIN-5 at meiotic and mitotic spindle poles.
    Title: NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of meiotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of meiotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Calmodulin;EF-hand domain-containing protein
NP_001300203.1
  • Confirmed by transcript evidence
NP_503386.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1156271..1158189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070985.7 → NP_503386.1  Calmodulin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503386.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16305
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 149
    PTZ00184; calmodulin; Provisional

  2. NM_001313274.3 → NP_001300203.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVX0
    Conserved Domains (1) summary
    PTZ00184
    Location:1 → 113
    PTZ00184; calmodulin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16305.3

Gene LinkOut

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