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lipl-3 Lipase lipl-3 [ Caenorhabditis elegans ]

Gene ID: 178572, updated on 2-Nov-2024

Summary

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Official Symbol
lipl-3
Official Full Name
Lipase lipl-3
Primary source
WormBase:WBGene00020016
Locus tag
CELE_R11G11.14
See related
AllianceGenome:WB:WBGene00020016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Involved in lipid catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lipl-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (521595..524218, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Nuclear Hormone Receptor family Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Secreted protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans. Buis A, et al. Cell Rep, 2019 Jul 23. PMID 31340142, Free PMC Article
  2. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. O'Rourke EJ, et al. Nat Cell Biol, 2013 Jun. PMID 23604316, Free PMC Article
  3. Surviving starvation simply without TFEB. Soukas AA, et al. PLoS Biol, 2019 May. PMID 31136567, Free PMC Article
  4. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions. Mony VK, et al. Proc Natl Acad Sci U S A, 2021 Oct 12. PMID 34607947, Free PMC Article
  5. HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence. Gerisch B, et al. Dev Cell, 2020 May 4. PMID 32302543

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
    Title: Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lipase lipl-3
NP_503233.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    521595..524218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070832.4 → NP_503233.1  Lipase lipl-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503233.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16956
    Conserved Domains (1) summary
    PLN02872
    Location:10 → 390
    PLN02872; triacylglycerol lipase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16956.2

Gene LinkOut

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