lipl-5 Lipase lipl-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lipl-5
Official Full Name: Lipase lipl-5
Primary source: WormBase:WBGene00022642
Locus tag: CELE_ZK6.7
See related: AllianceGenome:WB:WBGene00022642
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable hydrolase activity, acting on ester bonds. Involved in defense response to Gram-negative bacterium; lipid homeostasis; and triglyceride catabolic process. Located in lysosome. Is expressed in coelomocyte and intestine. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lipl-5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (385746..387740)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
Title: Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
Study characterized the lipid profile of Caenorhabditis elegans lipl-5 mutants, deficient for the LIPL-5 lipase, compared them with wild type worms, and found major alterations in mitochondrial lipids in the mutants, which were accompanied by significant changes in mitochondrial activity. Results indicate that LIPL-5 lipase is a determinant of mitochondrial functional remodeling in response to food withdrawal.
Title: Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans.

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General gene information

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Markers

ZK6.7 (e-PCR)
- UniSTS:306256

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Lipase lipl-5

NP_001360404.1

Confirmed by transcript evidence

NP_001368575.1

Confirmed by transcript evidence

NP_503184.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

385746..387740

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070783.5 → NP_503184.1 Lipase lipl-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503184.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AW68, A0A0K3AYF1, O61866

Conserved Domains (1) summary

PLN02872
Location:8 → 394

PLN02872; triacylglycerol lipase
NM_001380590.1 → NP_001368575.1 Lipase lipl-5 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN02872
Location:5 → 368

PLN02872; triacylglycerol lipase
NM_001372991.2 → NP_001360404.1 Lipase lipl-5 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN02872
Location:1 → 318

PLN02872; triacylglycerol lipase