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haf-1 [ Caenorhabditis elegans ]

Gene ID: 178522, updated on 22-Aug-2024

Summary

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Official Symbol
haf-1
Primary source
WormBase:WBGene00001811
Locus tag
CELE_C30H6.6
See related
AllianceGenome:WB:WBGene00001811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peptide transmembrane transporter activity. Involved in mitochondrial unfolded protein response; peptide transport; and protein import into mitochondrial matrix. Is integral component of mitochondrial inner membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (17376427..17379310)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Apple domain-containing protein Neighboring gene Altered inheritance of mitochondria protein 36, mitochondrial Neighboring gene 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein Neighboring gene protein-disulfide reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Bennett CF, et al. Nat Commun, 2014 Mar 24. PMID 24662282, Free PMC Article
  2. Mitochondrial Unfolded Protein Response to Microgravity Stress in Nematode Caenorhabditis elegans. Liu P, et al. Sci Rep, 2019 Nov 11. PMID 31712608, Free PMC Article
  3. Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. Runkel ED, et al. PLoS Genet, 2013. PMID 23516373, Free PMC Article
  4. Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity. Palikaras K, et al. Worm, 2015 Jul-Sep. PMID 26430570, Free PMC Article
  5. Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. Baker BM, et al. PLoS Genet, 2012. PMID 22719267, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. report that haf-1 is required for signaling within the UPR(mt) and for coping with misfolded protein stress.
    Title: The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 

General protein information

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Preferred Names
HAlF transporter (PGP related)
NP_503098.2
  • Product from WormBase gene class haf;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17376427..17379310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070697.7 → NP_503098.2  HAlF transporter (PGP related) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503098.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45278
    Conserved Domains (3) summary
    COG1132
    Location:82 → 641
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    cl00549
    Location:93 → 363
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:413 → 641
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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