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F52B11.2 putative phosphomannomutase [ Caenorhabditis elegans ]

Gene ID: 178364, updated on 2-Nov-2024

Summary

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Official Symbol
F52B11.2
Official Full Name
putative phosphomannomutase
Primary source
WormBase:WBGene00009925
Locus tag
CELE_F52B11.2
See related
AllianceGenome:WB:WBGene00009925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphomannomutase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM1 (phosphomannomutase 1) and PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F52B11.2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (14083568..14084695)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein Neighboring gene CXXC-type zinc finger protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphomannomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomannomutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative phosphomannomutase
NP_001255786.1
  • Confirmed by transcript evidence
NP_001255787.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14083568..14084695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268857.2 → NP_001255786.1  putative phosphomannomutase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255786.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E3W758, Q9XUE6
    Conserved Domains (2) summary
    TIGR01484
    Location:10 → 226
    HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
    pfam03332
    Location:31 → 252
    PMM; Eukaryotic phosphomannomutase

  2. NM_001268858.3 → NP_001255787.1  putative phosphomannomutase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255787.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XUE6
    Conserved Domains (2) summary
    COG0561
    Location:1 → 207
    Cof; Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only]
    pfam03332
    Location:2 → 223
    PMM; Eukaryotic phosphomannomutase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XUE6.2

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