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Y45F10D.7 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178346, updated on 2-Nov-2024

Summary

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Official Symbol
Y45F10D.7
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00012887
Locus tag
CELE_Y45F10D.7
See related
AllianceGenome:WB:WBGene00012887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in rRNA processing. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y45F10D.7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (13789081..13796224)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene NIF system FeS cluster assembly NifU N-terminal domain-containing protein Neighboring gene Integrin Cytoplasmic domain-Associated Protein homolog Neighboring gene Spindle assembly abnormal protein 6 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_001369795.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13789081..13796224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383239.2 → NP_001369795.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62477, O62478
    Conserved Domains (5) summary
    COG2319
    Location:499 → 680
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:233 → 271
    7WD40; WD40 repeat [structural motif]
    pfam04192
    Location:701 → 920
    Utp21; Utp21 specific WD40 associated putative domain
    pfam12894
    Location:424 → 470
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    cl29593
    Location:152 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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