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Mtx1 metaxin 1 [ Mus musculus (house mouse) ]

Gene ID: 17827, updated on 2-Nov-2024

Summary

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Official Symbol
Mtx1provided by MGI
Official Full Name
metaxin 1provided by MGI
Primary source
MGI:MGI:103025
See related
Ensembl:ENSMUSG00000064068 AllianceGenome:MGI:103025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtx; Gcap6
Summary
Predicted to be involved in mitochondrion organization. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cerebral cortex ventricular layer; pharyngo-tympanic tube; skin; and submandibular gland primordium. Orthologous to human MTX1 (metaxin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 88.2), adrenal adult (RPKM 34.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mtx1 in Genome Data Viewer
Location:
3 F1; 3 39.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89116388..89121214, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89209081..89213907, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45927 Neighboring gene secretory carrier membrane protein 3 Neighboring gene predicted gene 16069 Neighboring gene endosomal transmembrane epsin interactor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88994426-88994609 Neighboring gene STARR-positive B cell enhancer ABC_E275 Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E11197 Neighboring gene thrombospondin 3 Neighboring gene STARR-seq mESC enhancer starr_08226 Neighboring gene predicted gene, 57704 Neighboring gene microRNA 92b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing. Ono K, et al. Protein Cell, 2010 Feb. PMID 21088703, Free PMC Article
  2. SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin gene. Collins M, et al. Nucleic Acids Res, 1996 Oct 1. PMID 8871542, Free PMC Article
  3. Targeting and insertion of the cholesterol-binding translocator protein into the outer mitochondrial membrane. Rone MB, et al. Biochemistry, 2009 Jul 28. PMID 19552401, Free PMC Article
  4. Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure. Liu Y, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482915, Free PMC Article
  5. Structure and organization of the human metaxin gene (MTX) and pseudogene. Long GL, et al. Genomics, 1996 Apr 15. PMID 8660965

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAM complex IEA
Inferred from Electronic Annotation
more info
  
part_of SAM complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
metaxin-1
Names
mitochondrial outer membrane import complex protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161824.2 → NP_001155296.2  metaxin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161600
    UniProtKB/Swiss-Prot
    P47802
    Related
    ENSMUSP00000133282.2, ENSMUST00000173477.8
    Conserved Domains (2) summary
    cd03212
    Location:105 → 241
    GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
    pfam10568
    Location:23 → 143
    Tom37; Outer mitochondrial membrane transport complex protein

  2. NM_001357367.2 → NP_001344296.2  metaxin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161600
    UniProtKB/Swiss-Prot
    P47802
    UniProtKB/TrEMBL
    D3Z3F4
    Related
    ENSMUSP00000113986.3, ENSMUST00000119222.9
    Conserved Domains (2) summary
    cd03212
    Location:144 → 280
    GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
    pfam10568
    Location:23 → 182
    Tom37; Outer mitochondrial membrane transport complex protein

  3. NM_013604.3 → NP_038632.3  metaxin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161600
    Consensus CDS
    CCDS17494.2
    UniProtKB/Swiss-Prot
    P47802
    UniProtKB/TrEMBL
    E9Q6T4, F7C846, Q8R5C0
    Related
    ENSMUSP00000073261.6, ENSMUST00000073572.12
    Conserved Domains (2) summary
    cd03212
    Location:106 → 242
    GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
    pfam10568
    Location:23 → 144
    Tom37; Outer mitochondrial membrane transport complex protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89116388..89121214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47802.1 GenPept UniProtKB/Swiss-Prot:P47802

Gene LinkOut

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