Mt3 metallothionein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mt3provided by MGI
Official Full Name: metallothionein 3provided by MGI
Primary source: MGI:MGI:97173
See related: Ensembl:ENSMUSG00000031760 AllianceGenome:MGI:97173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mt-3
Summary: Enables zinc ion binding activity. Involved in several processes, including leptin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of oxygen metabolic process. Acts upstream of or within intracellular monoatomic cation homeostasis and negative regulation of neurogenesis. Located in synaptic vesicle. Is expressed in several structures, including decidua; ganglia; liver; ventral grey horn; and ventricular layer. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in frontal lobe adult (RPKM 335.8), cortex adult (RPKM 298.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.29 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (94879235..94880776)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94152607..94154148)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation.
Title: Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation.
A role of metallothionein-3 in radiation-induced autophagy in glioma cells.
Title: A role of metallothionein-3 in radiation-induced autophagy in glioma cells.
MT3 programs the phenotype and metabolic fate of M(IL-4) macrophages.
Title: Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.
the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization.
Title: Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization.
Circadian time and lighting could be involved in the regulation of the expression of melatonin receptors MTNR3 and Rorc.
Title: The expression of MTNR3 and nuclear receptors in murine leucocytes.
Mt3 may act through PDE3a to play a key role in Zinc dyshomeostasis and cell death in streptozotocin-treated islets.
Title: The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice.
Zn released from MT3 may contribute to VEGF induction.
Title: Methallothionein-3 contributes to vascular endothelial growth factor induction in a mouse model of choroidal neovascularization.
The entire MT3 peptide shows a high capacity to bind Cu(+) , provided that this occurs in a nonoxidative milieux. This reflects a peculiar property of this MT isoform, which senses different Cu contents in the environment in which it is synthesized.
Title: In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein.
MT-III can help protect against light-induced retinal damage compared to MT-I/II. Some of these effects may be exerted by its antioxidative potency.
Title: Metallothionein-III deficiency exacerbates light-induced retinal degeneration.
MT-3 is able to alter the Tg2576 phenotype in several aspects such as mortality and behavior in a gender-dependent manner.
Title: Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mt3 (e-PCR), detects polymorphism
- UniSTS:143925

Mt3 (e-PCR), detects polymorphism
- UniSTS:546511

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadmium ion binding	ISO Inferred from Sequence Orthology more info
enables cadmium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IC Inferred by Curator more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detoxification of cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy reserve metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular monoatomic cation homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leptin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxygen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of metal ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in astrocyte end-foot	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metallothionein-3

Names: GIF; MT-III; growth inhibitory factor; metallothionein-III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.