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him-3 HORMA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177462, updated on 17-Oct-2024

Summary

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Official Symbol
him-3
Official Full Name
HORMA domain-containing protein
Primary source
WormBase:WBGene00001862
Locus tag
CELE_ZK381.1
See related
AllianceGenome:WB:WBGene00001862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA binding activity. Involved in regulation of centriole-centriole cohesion and synaptonemal complex assembly. Located in lateral element. Is expressed in oocyte and spermatocyte. Orthologous to human HORMAD1 (HORMA domain containing 1) and HORMAD2 (HORMA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See him-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (6977508..6978765)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Guanyl-specific ribonuclease pgl-1 Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An asymmetric chromosome pair undergoes synaptic adjustment and crossover redistribution during Caenorhabditis elegans meiosis: implications for sex chromosome evolution. Henzel JV, et al. Genetics, 2011 Mar. PMID 21212235, Free PMC Article
  2. Finding and keeping your partner during meiosis. Couteau F, et al. Cell Cycle, 2004 Aug. PMID 15280669
  3. Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation. Zetka MC, et al. Genes Dev, 1999 Sep 1. PMID 10485848, Free PMC Article
  4. Chromosome-wide regulation of meiotic crossover formation in Caenorhabditis elegans requires properly assembled chromosome axes. Nabeshima K, et al. Genetics, 2004 Nov. PMID 15579685, Free PMC Article
  5. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. Sato-Carlton A, et al. PLoS Genet, 2020 Nov. PMID 33175901, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans.
    Title: Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HORMA domain-containing protein
NP_501078.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6977508..6978765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068677.7 → NP_501078.1  HORMA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501078.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBG0
    Conserved Domains (1) summary
    pfam02301
    Location:50 → 233
    HORMA; HORMA domain

RNA

  1. NR_131562.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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