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hil-2 Histone H1.2 [ Caenorhabditis elegans ]

Gene ID: 177390, updated on 2-Nov-2024

Summary

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Official Symbol
hil-2
Official Full Name
Histone H1.2
Primary source
WormBase:WBGene00001853
Locus tag
CELE_Y73B6BL.9
See related
AllianceGenome:WB:WBGene00001853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H1-8 (H1.8 linker histone). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hil-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_003282.8 (6294240..6295217)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans. Jedrusik MA, et al. Development, 2001 Apr. PMID 11245572
  2. Inheritance of paternal DNA damage by histone-mediated repair restriction. Wang S, et al. Nature, 2023 Jan. PMID 36544019, Free PMC Article
  3. Stable-isotope labeling with amino acids in nematodes. Larance M, et al. Nat Methods, 2011 Aug 28. PMID 21874007, Free PMC Article
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone H1.2
NP_001370852.1
  • Confirmed by transcript evidence
NP_741418.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6294240..6295217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383102.2 → NP_001370852.1  Histone H1.2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18649, P15796, Q8IU03, Q8MXR7

  2. NM_171909.8 → NP_741418.2  Histone H1.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741418.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15796
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15796.3

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