U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nape-1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 [ Caenorhabditis elegans ]

Gene ID: 177137, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
nape-1
Official Full Name
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1
Primary source
WormBase:WBGene00021371
Locus tag
CELE_Y37E11AR.4
See related
AllianceGenome:WB:WBGene00021371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in N-acylethanolamine metabolic process. Located in neuronal cell body. Is expressed in nervous system; pharynx; and vulval muscle. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See nape-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (3739520..3740880, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase siah-1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Endocannabinoid signaling regulates regenerative axon navigation in Caenorhabditis elegans via the GPCRs NPR-19 and NPR-32. Pastuhov SI, et al. Genes Cells, 2016 Jul. PMID 27193416
  2. Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans. Harrison N, et al. PLoS One, 2014. PMID 25423491, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1
NP_500408.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3739520..3740880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068007.5 → NP_500408.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500408.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q965X7
    Conserved Domains (1) summary
    cl23716
    Location:88 → 281
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q965X7.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools