lad-2 Ig-like domain-containing protein;Neuroglian [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lad-2
Official Full Name: Ig-like domain-containing protein;Neuroglian
Primary source: WormBase:WBGene00002243
Locus tag: CELE_Y54G2A.25
See related: AllianceGenome:WB:WBGene00002243
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables semaphorin receptor activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and regulation of axon guidance. Is integral component of plasma membrane. Is expressed in lumbar neurons and nerve ring neurons. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to several human genes including L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See lad-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 24

Sequence:: Chromosome: IV; NC_003282.8 (2964334..2978484, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LAD-2, a Caenorhabditis elegans L1CAM, functions in axon pathfinding.
Title: The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ig-like domain-containing protein;Neuroglian

NP_001023496.1

Confirmed by transcript evidence

NP_001023497.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

2964334..2978484 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028325.3 → NP_001023496.1 Neuroglian [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023496.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ECX2

Conserved Domains (6) summary

cd04978
Location:344 → 422

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

smart00410
Location:244 → 325

IG_like; Immunoglobulin like

cd00063
Location:921 → 1010

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:335 → 421

I-set; Immunoglobulin I-set domain

pfam00041
Location:823 → 909

fn3; Fibronectin type III domain

cl11960
Location:49 → 121

Ig; Immunoglobulin domain
NM_001028326.4 → NP_001023497.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023497.1

Status: REVIEWED

UniProtKB/TrEMBL

A5JVN7, H2L0R2

Conserved Domains (4) summary

cd04978
Location:344 → 422

Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)

smart00410
Location:244 → 325

IG_like; Immunoglobulin like

pfam07679
Location:335 → 421

I-set; Immunoglobulin I-set domain

cl11960
Location:49 → 121

Ig; Immunoglobulin domain